| 含有致死基因型的质量性状基因定位的统计方法 |
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| 引用本文： | 林飞,章元明.含有致死基因型的质量性状基因定位的统计方法[J].南京农业大学学报,2006,29(4):19-22. |
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| 作者姓名： | 林飞 章元明 |
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| 作者单位： | 南京农业大学作物遗传与种质创新国家重点实验室/国家大豆改良中心,江苏,南京,210095 |
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| 基金项目： | 国家自然科学基金;江苏省自然科学基金;教育部跨世纪优秀人才培养计划 |
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| 摘 要： | 假定某一质量性状受单基因控制，且在纯合显性（或纯合隐性）时会致死，造成不符合Mendelian分离比。在F2群体中，根据分子标记和该基因的连锁关系，获得标记与性状的各种表型类别、频率和植株数，通过Fisher最大似然法，推导出估计重组率的方程和标准误公式。Monte Carlo模拟研究表明，最大似然法得到的重组率估计值与真值接近，并验证了重组率估计值标准误公式。
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| 关 键 词： | 致死基因型 重组率 标记 最大似然方法 |
| 文章编号： | 1000-2030(2006)04-0019-04 |
| 收稿时间： | 11 21 2005 12:00AM |
| 修稿时间： | 2005年11月21 |
Statistical method for mapping the gene of qualitative trait with one lethal genotype |
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| LIN Fei,ZHANG Yuan-ming.Statistical method for mapping the gene of qualitative trait with one lethal genotype[J].Journal of Nanjing Agricultural University,2006,29(4):19-22. |
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| Authors: | LIN Fei ZHANG Yuan-ming |
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| Institution: | State Key Laboratory of Crop Genetics and Germplasm Enhancement/National Center of Soybean Improvement, Nanjing Agricultural University, Nanjing 210095, China |
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| Abstract: | Provided that a qualitative trait is controlled by a single gene and individuals with homogeneous genotype, AA or aa, are not survivable, the segregation ratio is distorted from Mendelian segregation ratio and the regular mapping methods are unavailable. Based on the linkage relationship between marker and the gene, the number and the frequencies of various phenotypes for both marker and the above-mentioned qualitative trait in F2 population can be used to estimate the recombination fraction between the marker and the single gene, and its standard error. The results from Monte Carlo simulation show that the estimate of recombination fraction is consistent with its true value, and the formula of its standard error is validated. |
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| Keywords: | lethal genotype recombination fraction marker maximum likelihood method |
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