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| 过氧化氢氧化对甲基苯甲醛制备对甲基苯甲酸研究 | |
| 引用本文： | 于丽颖,罗亚楠,刘立群,方圆.过氧化氢氧化对甲基苯甲醛制备对甲基苯甲酸研究[J].安徽农业科学,2012,40(1):257-258. |
| 作者姓名： | 于丽颖 罗亚楠 刘立群 方圆 |
| 作者单位： | 1. 吉林化工学院化学与制药工程学院,吉林吉林,132022 2. 吉林石化公司有机合成厂,吉林吉林,132021 3. 北华大学医学检验学院,吉林吉林,132013 |
| 摘 要： | 目的]探讨过氧化氢氧化对甲基苯甲醛制备对甲基苯甲酸的工艺条件。方法]以30%过氧化氢为氧化剂,在碱性条件下氧化对甲基苯甲醛制备对甲基苯甲酸,采用正交试验探讨了对甲基苯甲酸的最佳合成工艺条件,并通过测定熔点、红外光谱表征了目标化合物。结果]优化的合成条件为:物料摩尔比对甲基苯甲醛∶30%过氧化氢=1∶6,反应温度为40℃;氢氧化钾浓度为60%。该工艺条件下,对甲基苯甲酸产率达到91%以上;重复性试验结果显示,对甲基苯甲酸的平均收率达91.7%。结论]为对甲基苯甲酸的工业化生产奠定了基础。 |
| 关 键 词： | 对甲基苯甲醛 过氧化氢 对甲基苯甲酸 氧化 |
Oxidation of p-methyl Benzaldehyde to p-methylbenzoic Acid by H2O2 |
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| Institution: | YU Li-ying et al(Department of Chemistry and Pharmacy,Jilin Institute of Chemistry Technology,Jilin,Jilin 132022) |
| Abstract: | Objective] The aim was to explore oxidation conditions of p-methyl benzaldehyde to p-methylbenzoic acid by H2O2.Method] Using hydrogen peroxide as an oxidant catalyze,p-methyl benzaldehyde was oxidized into p-methylbenzoic acid under the alkaline condition,and the operation conditions were optimized by orthogonal test.The product was determined by melting point and infrared spectrometry.Result] The optimal operation conditions were as followed: the molar ratio of p-methyl benzaldehyde and 30% H2O2 was 1∶ 6;the reaction temperature was 40 ℃;and the concentration of KOH was 60%.Under the best reaction conditions,the yield of p-methylbenzoic acid reached more than 91%,and the reproducibility experiment result showed that the average yield of p-methylbenzoic acid reached 91.7%.Conclusion] The research lays a foundation for the industrial production of p-methylbenzoic acid. |
| Keywords: | p-methyl benzaldehyde Hydrogen peroxide p-methylbenzoic acid Oxidation |
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