The preparation of polyurethane foam combined with pH-sensitive alginate/bentonite hydrogel for wound dressings |
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| Authors: | Seung-Taek Oh Woo-Ram Kim Sung-Hoon Kim Yong-Chan Chung Jong-Shin Park |
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| Institution: | (1) Graduate School of Engineering, Fukui University of Technology, 3-6-1, Gakuen, Fukui 910-8505, Japan;(2) Lignocel Research, 73-8, Yatsumata, Fukui 910-3558, Japan; |
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| Abstract: | Polyurethane (PU) foam was combined with protein drug-loaded pH-sensitive alginate-bentonite hydrogel for wound dressings.
Alginate is a linear copolymer composed of 1–4-linked β-D-mannuronic acid (M) and its c-5-epimer α-Lguluronic acid (G). The amount of (M) and (G) and their sequential distribution are varied depending on the alginate source.
Soluble sodium alginate can become a hydrogel when cross-linked with divalent cations and has widespread applications in the
food, drink, pharmaceutical and bioengineering industries. Recently, it has been also proposed as a biomaterial for drug delivery
systems. Bentonites are the natural inorganic polymers consisting of a large proportion of expandable clay minerals with a
three-layer structure such as montmorillonite, beidellite, nontronite, etc. They are important adjutants and supports for
medical products, and they have many useful physicochemical, mechanical, and biological properties such as absence of toxicity,
indifference to other raw materials, sorption, swelling, and complex formation properties. Alginate-bentonite hydrogels were
prepared at concentration ratios of 10/0, 7/3, 5/5, 3/7. PU foams were prepared using hydrophilic polyols. We investigated
the controlled release of a protein drug from PU foam combined with alginate-bentonite hydrogel at different pH values of
4.2, 5.2, 7.2, 8.2. The mechanical properties and cytotoxicity tests of this foam were also studied. |
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