Anti-inflammatory, antioxidant and antifungal furanosesquiterpenoids isolated from Commiphora erythraea (Ehrenb.) Engl. resin |
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| Authors: | Fraternale Daniele Sosa Silvio Ricci Donata Genovese Salvatore Messina Federica Tomasini Sabrina Montanari Francesca Marcotullio Maria Carla |
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| Institution: | a Dipartimento di Scienze dell'Uomo, dell'Ambiente e della Natura, Sez. Biologia Vegetale, Università degli Studi di Urbino “Carlo Bo”, Via Bramante, 28-61029 Urbino, Italy;b Dipartimento dei Materiali e delle Risorse Naturali, Università degli Studi di Trieste, Via A. Valerio, 6-34127 Trieste, Italy;c Dipartimento di Scienza del Farmaco, Università degli Studi di Chieti, Via de' Vestini, 31-66013 Chieti, Italy;d Dipartimento di Chimica e Tecnologia del Farmaco, Sez. Chimica Organica, Università degli Studi di Perugia, Via del Liceo, 1-06123 Perugia, Italy |
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| Abstract: | The topical anti-inflammatory, free radical scavenging and antifungal activities of essential oils and extracts of Commiphora erythraea (Ehrenb.) Engl. resin were investigated. The hexane extract significantly inhibited oedema when applied topically in Croton oil-induced ear oedema assay in mice. The same extract showed antioxidant activity in DPPH radical scavenging assay. A bioguided separation of the hexane extract led to the isolation of furanosesquiterpenoids 1 and 2 that showed a weak antifungal activity, while compounds 3-5 resulted to be antioxidant (EC50 4.28, 2.56 and 1.08 mg/mL, respectively) and anti-inflammatory (30, 26 and 32% oedema reduction, respectively). |
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| Keywords: | Antifungal Anti-inflammatory Antioxidant Commiphora erythraea DPPH Croton oil test |
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