| 手性农药毒性评价进展 |
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| 引用本文： | 刘维屏,张颖.手性农药毒性评价进展[J].浙江大学学报(农业与生命科学版),2012(1):63-70. |
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| 作者姓名： | 刘维屏 张颖 |
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| 作者单位： | 浙江大学环境与资源学院环境科学研究所 |
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| 基金项目： | 国家杰出青年科学基金资助项目(20225721);国家自然科学基金资助项目(30771255) |
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| 摘 要： | 长期以来,手性农药都被当作单一化合物进行环境行为和生态毒性研究,但是由于手性农药对映体与生物大分子相互作用的立体选择性,手性农药对动物及人类的毒性作用可能具有对映体选择性.本文介绍了有机磷、有机氯、拟除虫菊酯、苯基吡唑等手性农药对内分泌、神经、免疫、生殖、发育等毒性作用的对映体选择性,分析了对映体选择性产生的机制,在此基础上提出了未来的研究方向.
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| 关 键 词： | 手性农药 对映体选择性 内分泌干扰 神经毒性 免疫毒性 发育毒性 毒性机制 |
Progress in potential toxicity of chiral pesticides |
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| LIU Wei-ping,ZHANG Ying.Progress in potential toxicity of chiral pesticides[J].Journal of Zhejiang University(Agriculture & Life Sciences),2012(1):63-70. |
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| Authors: | LIU Wei-ping ZHANG Ying |
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| Institution: | (Institute of Environmental Science,College of Environmental and Resource Sciences,Zhejiang University,Hangzhou 310058,China) |
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| Abstract: | In the past,chiral pesticides were explored as racemic mixtures in environmental fate and ecotoxicities.However,as a result of the enantioselective interactions with chiral molecules,the enantiomers of chiral pesticides may have different potential toxicities to humans and animals.The present review introduced recent findings on enantioselective endocrine disruption,neurotoxicity,immunotoxicity,reproductive and developmental toxicity of organophosphorus,organochlorines,pyrethroids and phenylpyrazole pesticides,as well as the underlying mechanisms.Furthermore,the developmental trends of future investigations were discussed. |
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| Keywords: | chiral pesticides enantioselectivity endocrine disruption neurotoxicity immunotoxicity developmental toxicity toxic mechanism |
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