Sedative effects of two doses of alfaxalone in combination with methadone and a low dose of dexmedetomidine in healthy Beagles |
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| Institution: | 1. Centre Vétérinaire Daubigny, Québec, QC, Canada;2. Department of Clinical Sciences, Faculté de médecine vétérinaire, Université de Montréal, Saint-Hyacinthe, QC, Canada;3. Foundation for Veterinary Aid International, St-Charles-sur-le-Richelieu, QC, Canada;1. Department of Veterinary Medicine and Surgery, Universidade Federal Rural do Rio de Janeiro, UFRRJ, Seropédica, RJ, Brazil;2. Department of Veterinary Medicine, Universidade Federal do Paraná, UFPR, Curitiba, PR, Brazil;1. Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada;2. Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada;1. Bristol Veterinary School, University of Bristol, Langford, North Somerset, UK;2. Arthritis Research UK Pain Centre and Division of Animal Sciences, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, UK;3. Comparative Pain Research and Education Centre, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA;4. Comparative Medicine Institute, North Carolina State University, Raleigh, NC, USA;5. Center for Pain Research and Innovation, UNC School of Dentistry, Chapel Hill, NC, USA;1. Section of Veterinary Clinics and Animal Production, Department of Emergency and Organ Transplantation, Aldo Moro University, Bari, Italy;2. PhD Course in Organs and Tissues Transplantation and Celluar Therapies, Department of Emergency and Organ Transplantations, Aldo Moro University, Bari, Italy;1. Veterinary Science Graduate Program, University of Franca, Franca, SP, Brazil;2. Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, USA;3. Graduate Program in Animal Science, Vila Velha University, Vila Velha, ES, Brazil |
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| Abstract: | ObjectiveTo evaluate the sedative effects of two doses of alfaxalone when added to a combination of dexmedetomidine and methadone injected intramuscularly (IM) in healthy Beagles.Study designRandomized, blinded, crossover, experimental study.AnimalsA group of six adult Beagles.MethodsDogs were sedated on three different occasions with IM dexmedetomidine (3 μg kg–1) and methadone (0.3 mg kg–1) combined with two doses of alfaxalone (0.5 and 1 mg kg–1; A0.5 and A1, respectively) or saline (A0). Quality of sedation, response to tail clamping and rectal temperature were recorded at baseline, 5, 15, 25, 35 and 45 minutes. Pulse and respiratory rates, oxygen saturation of haemoglobin (SpO2) and noninvasive blood pressure (NIBP) were recorded every 5 minutes. Onset of sedation and duration of recumbency, response to venous catheterization and recovery quality were assessed. Physiological variables (analysis of variance) were analysed between treatments and within treatments compared with baseline (Student t test). Nonparametric data were analysed using Friedman and Cochran’s Q tests. Significance was p < 0.05.ResultsSedation scores were significantly higher when alfaxalone was co-administered (area under the curve; p = 0.024, A0.5; p = 0.019, A1), with no differences between doses. Onset of sedation was similar, but duration of recumbency was longer in A0.5 than in A0 median (minimum–maximum), 43 (35–54) versus 30 (20–47) minutes, p = 0.018], but not in A1. Response to venous catheterization and tail clamping, and quality of recovery (acceptable) presented no differences between treatments. A decrease in all physiological variables (compared with baseline) was observed, except for NIBP, with no differences between treatments. All dogs required oxygen supplementation due to reduced SpO2.Conclusions and clinical relevanceAdding alfaxalone to methadone and dexmedetomidine enhanced sedation and duration of recumbency. Although cardiopulmonary depression was limited, oxygen supplementation is advisable. |
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| Keywords: | alfaxalone dexmedetomidine dog methadone sedation |
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