| 周效磺胺(SDM′)在马体内的代谢动力学的研究 |
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| 引用本文： | 李涛,解启英,王振隆,佟恒敏,李世贤,张淑静,高贵山,郭万松,姜宝才,王洪淑,徐桂琴.周效磺胺(SDM′)在马体内的代谢动力学的研究[J].东北农业大学学报,1982(1). |
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| 作者姓名： | 李涛 解启英 王振隆 佟恒敏 李世贤 张淑静 高贵山 郭万松 姜宝才 王洪淑 徐桂琴 |
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| 作者单位： | 东北农学院畜牧兽医系，东北农学院畜牧兽医系，东北农学院畜牧兽医系，东北农学院畜牧兽医系，黑龙江省兽医药检所，黑龙江省兽医药检所，海伦县畜牧科，海伦县畜牧科，海伦县兽医院，海伦县兽医院，海伦县兽医院 |
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| 摘 要： | 本文报告了周效磺胺在四匹健康成年马体内的药代动力学过程。根据二室开放式模型的数学公式,算出了周效磺胺有关的一些药代动力学参数。周效磺胺的生物半衰期为14.13±2.15小时,其有效浓度维持时间为10.03±3.50小时。周效磺胺对马不是周效,而是属于中效磺胺。静脉推注50mg/kg体重,其负荷剂量(突击剂量)为115mg,给药间隔时间为10小时。
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PHARMACOKINETICS OF SULFAMETHOXINE IN THE HORSES |
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| Abstract: | This papar described pharmaco, kinetics process of weekly-acting sulfonamide in four healthy adult horses. Some parameters of pharmacokinetics on weeklyacting Sulfonamide were calculated by mathematical equation associated with twocompartment open model. The t 1/2 of weekly-acting Sulfonamide was 14.13±2.15 hours and the TCP(ther) was 10.03±3.50 hours. The weekly-acting Sulfonamide for the horses was not weekly-acting, it was only medium sulfanamide. Following post-intravenous administrastion (Bolus)(50mg/kg body weight)its loading dose was 115mg, and its interval of the adbministration was 10 hours. |
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