Feasibility and repeatability of thermal quantitative sensory testing in normal dogs and dogs with hind limb osteoarthritis-associated pain |
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| Authors: | Morika D Williams Amy E Kirkpatrick Emily Griffith Javier Benito Jon Hash BDX Lascelles |
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| Institution: | 1. Comparative Pain Research Laboratory (CPRL), Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA;2. Center for Comparative Medicine and Translational Research, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA;3. Department of Statistics, North Carolina State University, Raleigh, NC 27695, USA;4. Department of Clinical Sciences Surgery Section, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA;1. Faculty of Veterinary Medicine, Small Animal Hospital, University of Glasgow, 464 Bearsden Road, Glasgow G61 1QH, UK;2. Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, Faculty of Health and Life Sciences, University of Liverpool, Liverpool CH64 7TE, UK;1. Department of Clinical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA;2. Department of Animal and Rangeland Sciences, Oregon State University, Corvallis, OR 97331, USA;3. Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA;4. School of Mechanical, Industrial, and Manufacturing Engineering, Oregon State University, Corvallis, OR 97331, USA |
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| Abstract: | The objectives of this study were to determine whether thermal quantitative sensory testing (QST) can be performed in client-owned dogs, is repeatable and whether QST differs between normal dogs and dogs with hind limb osteoarthritis (OA). This clinical, prospective, observational study used clinically normal dogs (n = 23) and dogs with OA-associated hind limb pain (n = 9). Thermal QST was performed in standing dogs using a high-powered light source delivered by a previously validated system. Dogs were tested on two occasions, 2 weeks apart. Five tests were performed on each hind limb at each time point. Repeated measures analysis of variance was used to evaluate the effects of leg, time point and OA/normal status on thermal threshold latencies (TTL). Additionally, paired t tests were used to compare the TTL of left and right limbs within groups and between time points.Thermal thresholds were successfully measured in 32 client-owned dogs without prior training. TTL were significantly different between normal and OA dogs (P = 0.012). There was no difference between limbs (P = 0.744) or time periods (P = 0.572), when analyzed by repeated measures analysis of variance, and no interactions between group and limb, visit and limb, or visit and group. In conclusion, thermal thresholds can be measured in client owned dogs with no prior training and are repeatable from week to week. Further data are required to determine if OA results in thermal hypoalgesia as measured at the distal hind limb and whether this is an indication of central sensitization. |
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| Keywords: | Canine Quantitative sensory testing Osteoarthritis Thermal threshold |
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