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Further data to the aetiology, pathogenesis and therapy of infectious bovine keratoconjunctivitis
Authors:Attila Nagy   mile Vandersmissen  Pl Kapp
Institution:

a Animal Health and Food Control Station, Veszprém, France

b Pfizer Corporation, Eastern European Division, Brussels, France

c Department of Pathology, University of Veterinary Science, Budapest, France

Abstract:Out of a total of 224 bovine eye secretions, 126 Moraxella bovis and 64 Neisseria ovis strains were isolated. The pathogenesis and histological lesions caused by Neisseria ovis have been studied on the eyes of three calves naturally affected with IBK, using electron microscopy.

Neisseria ovis caused in 1–12 weeks old calves acute, transient and mostly benign serous conjunctivitis with only slight affection of the cornea. More rarely erosions and even ulceration of the cornea have been observed.

Moraxella bovis and Neisseria ovis strains proved nearly unanimously sensitive in vitro to chloramphenicol, neomycin, oxytetracyclin, nitrofurantoin, erythromycin and cefoperazone. Other antibiotics and chemotherapeutics inhibited the growth of these agents only partly or were ineffective.

Experimental therapy has been carried out using a single i.m. injection of Terramycin/LA inj. (Pfizer) in a dose of 20 mg/kg body mass, repeated if necessary after 72–96 h. This formulation proved more effective and practical than treatments used earlier.

Keywords:Infectious bovine keratoconjunctivitis IBK  oxytetracycline long-acting OTC/LA  transmission electron microscopy TEM  scanning electron microscopy SEM  smooth colonies SC-type  minimal inhibitory concentration MIC  Moraxella bovis  Neisseria ovisAuthor Keywords: Kérato-conjunctivite infectieuse bovine  oxytetracycline long-acting OTC/LA  microscopie électronique à transmission  EMT  electron microscopie scanning  EMS  colonies lisses  type SC  concentration minimale inhibitrice  CMI  Moraxella bovis  Neisseria ovis
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