Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells |
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| Authors: | Mora J Rodrigo Iwata Makoto Eksteen Bertus Song Si-Young Junt Tobias Senman Balimkiz Otipoby Kevin L Yokota Aya Takeuchi Hajime Ricciardi-Castagnoli Paola Rajewsky Klaus Adams David H von Andrian Ulrich H |
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| Institution: | CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA. mora@cbr.med.harvard.edu |
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| Abstract: | Normal intestinal mucosa contains abundant immunoglobulin A (IgA)-secreting cells, which are generated from B cells in gut-associated lymphoid tissues (GALT). We show that dendritic cells (DC) from GALT induce T cell-independent expression of IgA and gut-homing receptors on B cells. GALT-DC-derived retinoic acid (RA) alone conferred gut tropism but could not promote IgA secretion. However, RA potently synergized with GALT-DC-derived interleukin-6 (IL-6) or IL-5 to induce IgA secretion. Consequently, mice deficient in the RA precursor vitamin A lacked IgA-secreting cells in the small intestine. Thus, GALT-DC shape mucosal immunity by modulating B cell migration and effector activity through synergistically acting mediators. |
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