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A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A |
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| Authors: | Cruz-Migoni Abimael Hautbergue Guillaume M Artymiuk Peter J Baker Patrick J Bokori-Brown Monika Chang Chung-Te Dickman Mark J Essex-Lopresti Angela Harding Sarah V Mahadi Nor Muhammad Marshall Laura E Mobbs George W Mohamed Rahmah Nathan Sheila Ngugi Sarah A Ong Catherine Ooi Wen Fong Partridge Lynda J Phillips Helen L Raih M Firdaus Ruzheinikov Sergei Sarkar-Tyson Mitali Sedelnikova Svetlana E Smither Sophie J Tan Patrick Titball Richard W Wilson Stuart A Rice David W |
| Institution: | Department of Molecular Biology and Biotechnology, Krebs Institute, University of Sheffield, Sheffield S10 2TN, UK. |
| Abstract: | The structure of BPSL1549, a protein of unknown function from Burkholderia pseudomallei, reveals a similarity to Escherichia coli cytotoxic necrotizing factor 1. We found that BPSL1549 acted as a potent cytotoxin against eukaryotic cells and was lethal when administered to mice. Expression levels of bpsl1549 correlate with conditions expected to promote or suppress pathogenicity. BPSL1549 promotes deamidation of glutamine-339 of the translation initiation factor eIF4A, abolishing its helicase activity and inhibiting translation. We propose to name BPSL1549 Burkholderia lethal factor 1. |
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