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Age-related changes in calretinin-immunoreactive periglomerular cells in the rat main olfactory bulb
Authors:Hwang In Koo  Yoo Ki-Yeon  Nam Young Sam  Choi Jung Hoon  Seo Kangmoon  Lee In Se  Jung Ju Young  Kang Tae-Cheon  Oh Yang-Seok  Won Moo Ho
Institution:Department of Anatomy, College of Medicine, Hallym University, Chunchon, South Korea.
Abstract:The changes of calretinin (CR)-immunoreactive periglomerular cells in the glomerular layer of the main olfactory bulb (MOB) were investigated in rats differing ages from postnatal month 1 (PM 1) to PM 24. The number of cresyl violet-positive periglomerular cells was similar between PM 1 and PM 12, but they decreased slightly in the PM 24 group. The size of CR-immunoreactive periglomerular cells in the glomerular layer increased with age, while their numbers did not change significantly in the PM 6-PM 24 groups. In the PM 24 group, numbers of CR-positive periglomerular cell bodies and their processes decreased, while the size of CR-positive cell bodies in the glomeruli was larger than that of the previous groups. These results suggest that CR-immunoreactive periglomerular cells in the rat MOB are well-developed in the PM 6 group, and that periglomerular cells in the PM 24 group show poor CR-immunoreactivity compared to those in the PM 6 group.
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