| 母带犊牛与离母犊牛的血清代谢组学差异 |
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| 引用本文： | 罗焱鹏,李梦雅,王之盛,万发春,薛白,王立志,闫向民,彭全辉.母带犊牛与离母犊牛的血清代谢组学差异[J].动物营养学报,2022,34(2):1109-1118. |
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| 作者姓名： | 罗焱鹏 李梦雅 王之盛 万发春 薛白 王立志 闫向民 彭全辉 |
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| 作者单位： | 四川农业大学动物营养研究所,牛低碳养殖与安全生产重点实验室,成都 611130;山东省农业科学院畜牧兽医研究所,济南 250100;新疆畜牧科学院,乌鲁木齐 830000 |
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| 基金项目： | “十三五”国家重点研发计划(2018YFD0501801);四川省科技厅基础研究(2019YJ0434);四川省教育厅重点项目(18ZA0381)。 |
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| 摘 要： | 本试验旨在比较母带犊牛和离母犊牛的血清代谢组学差异,为开发犊牛代乳粉提供方向.挑选8头健康且体重(13.88±0.54)kg]接近的新生犊牛(牦牛 ×犏牛♀)为母带犊牛组,犊牛随母哺乳;另外挑选8头体重(13.75±0.82)kg]接近的新生犊牛(牦牛 ×犏牛♀)为离母犊牛组,犊牛饲喂代乳粉.2组犊牛10 d后自由...
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| 关 键 词： | 代乳粉 代谢组学 抗氧化能力 离母犊牛 母带犊牛 |
Serum Metabolomic Differences between Calves with Dam and Calves without Dam |
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| LUO Yanpeng,LI Mengya,WANG Zhisheng,WAN Fachun,XUE Bai,WANG Lizhi,YAN Xiangmin,PENG Quanhui.Serum Metabolomic Differences between Calves with Dam and Calves without Dam[J].Acta Zoonutrimenta Sinica,2022,34(2):1109-1118. |
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| Authors: | LUO Yanpeng LI Mengya WANG Zhisheng WAN Fachun XUE Bai WANG Lizhi YAN Xiangmin PENG Quanhui |
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| Institution: | (Low Carbon Breeding Cattle and Safety Production University Key Laboratory of Sichuan Province,Animal Nutrition Institute,Sichuan Agricultural University,Chengdu 611130,China;Institute of Animal Husbandry and Veterinary Science,Shandong Academy of Agricultural Sciences,Ji’nan 250100,China;Xinjiang Academy of Animal Science,Urumqi 830000,China) |
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| Abstract: | This experiment was conducted to compare the serum metabolomic differences between calves with dam and calves without dam,and to provide a direction for the development of calf milk replacer. Eight healthy newborn calves(yak ♂×Pian cattle♀)with similar body weight(13.88±0.54)kg]were selected as the calves with dam group,and calves suckled with heifers;another eight healthy newborn calves(yak ♂×Pian cattle♀)with similar body weight(13. 75 ± 0. 82)kg]were selected as calves without dam group,and calves fed the milk replacer. Calves in 2 groups were free feeding the same diet after 10 days. The experiment lasted for 90 days. The blood samples of calves in 2 groups were collected before morning feeding on the day of test completion,the metabolomics analysis was performed on the serum samples using ultrahigh performance liquid chromatography/quadrupole time of flight mass spectrometry(UPLC-QTOF/MS). The fold change(FC),variable importance in projection(VIP)and P-value of the t-test were used as the screening basis,and the screening criteria were FC<0.5 or FC>1.5,VIP>1 and P<0.01. The results showed as that a total of 30 significant metabolics such as DL-3 phenyllactic acid,D-sorbitol and hesperidin were screened(FC < 0.5 or FC>1.5,VIP>1 and P<0.01). The pathways of significant metabolites analysis showed that the 5 metabolic pathways of D-glutamine and D-glutamate metabolism,taurine and hypotaurine metabolism,arginine and proline metabolism,glyoxylate and dicarboxylate metabolism and glutathione metabolism were the most correlated pathway with the changes of serum metabolites. The contents of antibacterial substances such as DL-3-phenyllactic acid,lauric acid and L-malic acid and antioxidant substances such asγ-glutamylcysteine,L-glutamate and taurine etc in serum of calves without dam were significantly lower than those of calves with dam(FC<0.5 or FC>1.5,VIP>1 and P<0.01). The lipocatabolism was enhanced of calves without dam,and the contents of non-esterified fatty acids such as stearic acid,eicosicanoic acid and icosenicanoic acid in serum were significantly higher than those of calves with dam(FC<0.5 or FC>1.5,VIP>1 and P<0.01). In addition,the content of mevalic acid in serum,an important intermediate in the synthesis of cholesterol and terpenoids,was significantly lower of calves without dam than that of calves with dam(FC<0.5 or FC>1.5,VIP> 1 and P <0.01). In conclusion,the antibacterial and antioxidant capacities of calves without dam feeding milk replacer are weaker than those of calves with dam;the fat catabolism capacity is better than that of calves with dam,and the fat anabolism is weaker than that of calves with dam.Chinese Journal of Animal Nutrition,2022,34(2):1109-1118] |
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| Keywords: | milk replacer metabolomics antioxidant capacity calves without dam calves with dam |
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