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Long-term antidepressant treatment decreases spiroperidol-labeled serotonin receptor binding |
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| Authors: | S J Peroutka S H Snyder |
| Abstract: | Antidepressants compete at several neurotransmitter receptor binding site, but drug affinities do not correlate with clinical efficacy. Long-term, but not short-term, antidepressant treatment decreases the numbers of both serotonin and beta-adrenergic receptors. The decrease in the number of receptor sites is most marked for 3H]spiroperidol-labeled serotonin receptors and is characteristic for antidepressants of several classes. |
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