Xanthine oxidase inhibitory lanostanoids from Ganoderma tsugae |
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| Institution: | 1. Faculty of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan;2. Department of Life Science, National Taitung University, Taitung 95002, Taiwan;3. School of Medicine, Fu-Jen Catholic University, New Taipei City 24205, Taiwan;4. Faculty of Fragrance and Cosmetics, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan;5. Department of Biological Science and Technology, School of Medicine, China Medical University, Taichung 40402, Taiwan;1. State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, PR China;2. Savaid Medical School, University of Chinese Academy of Sciences, Beijing, PR China;3. Institute of Vegetable Research, Tibet Academy of Agriculture and Animal Science, PR China;4. Tibet Lingzhi Bio-tech Co., Ltd, No. 15, Galsang Road, Economic & Hi-Tech Development Area, Lhasa, PR China;5. State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Science, Beijing, PR China |
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| Abstract: | Two new lanostanoids, 3α-acetoxy-22-oxo-5α-lanosta-8,24-dien-21-oic acid, named tsugaric acid D (1) and 16α-hydroxy-3-oxo-5α-lanosta-6,8,24(241)-trien-21-oic acid, named tsugaric acid E (2) were isolated from the fruit bodies of Ganoderma tsugae. The structures 1 and 2 were determined by spectroscopic methods. Compound 1 and known compounds 3 and 6 exhibited significant inhibitory effects on xanthine oxidase (XO) activity with an IC50 values of 90.2 ± 24.2, 116.1 ± 3.0, and 181.9 ± 5.8 μM, respectively. Known compound 5 was able to protect human keratinocytes against damage induced by UVB light, which showed 5 could protect keratinocytes from photodamage. The 1 and 5 μM 1 combined with 5 μM cisplatin, respectively, enhanced the cytotoxicity induced by cisplatin. It suggested that 1 and 5 μM 1 combined with low dose of cisplatin may enhance the therapeutic efficacy of cisplatin and reduce side effect and cisplatin resistant. |
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