Four new C18-diterpenoid alkaloids with analgesic activity from Aconitum weixiense |
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| Institution: | 1. School of Agriculture, Yunnan University, Kunming 650091, PR China;2. College of Agriculture and Biotechnology, Yunnan Agricultural University, Kunming 650201, PR China;3. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China;1. Kunming Key Laboratory of Respiratory Disease, Kunming University, Kunming 650214, PR China;2. Yun Center for Disease Prevention and Control, Kunming 650022, PR China;3. Yunnan University of Traditional Chinese Medicine, Kunming 650500, PR China |
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| Abstract: | Four new C18-diterpenoid alkaloids, weisaconitines A–D (1–4), were isolated from Aconitum weixiense. Based on extensive UV, IR, MS, 1D and 2D NMR analyses, their structures were elucidated as 8-O-ethyldolaconine (1), 4-demethylgenicunine B (2), 14-oxoaconosine (3), and 8-O-ethylaconosine (4). The analgesic activity of compound 4 was studied with CH3COOH-induced writhing model in mice. Compound 4 showed writhing inhibitions of 24% (50 mg/kg), 26% (100 mg/kg) and 34% (200 mg/kg), respectively, as compared to the reference drug aspirin (63%) at a dose of 200 mg/kg. |
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