New amide alkaloids from Piper longum |
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| Institution: | 2. Medicinal and Natural Products Chemistry, The University of Iowa, Iowa City, Iowa, USA;2. Academy of Scientific and Innovative Research, New Delhi, India;1. Department of Oral and Maxillofacial Pathology, School of Dentistry, Kyung HeeUniversity,26, Kyungheedae-ro, Dongdaemun-gu,Seoul02453, South Korea;2. National Development Institute of Korean Medicine, Gyeongsan38540, South Korea |
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| Abstract: | Bioassay-guided phytochemical investigation on Piper longum resulted in the isolation of two new compounds. By analyses of the MS, IR, UV, 1D and 2D NMR data, the two new compounds were identified as 3β, 4α-dihydroxy-1-(3-phenylpropanoyl)-piperidine-2-one (1) and (2E, 4E, 14Z)-6-hydroxyl-N-isobutyleicosa-2,4,14-trienamide (2). In vitro anti-HBV bioassay demonstrated compound 1 possessed remarkable activity suppressing the secretion of HBeAg in Hep G2.2.15 cell line, with an IC50 value of 0.21 mM and SI value of 16.4. |
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