Platelet-activating factor (PAF)-antagonists of natural origin |
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| Institution: | 1. Department of Pharmacology, R.V.N.I. Dadri, Greater Noida, 201301, Uttar Pradesh, India;2. Department of Natural Products, National Institute of Pharmaceutical Education and Research, Sec. 67, S.A.S. Nagar-160062, Punjab, India;3. Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Baghpat bypass, NH-58, meerut-250005, Uttar Pradesh, India;1. Department of Physiology and Pathophysiology, School of Basal Medical Science, Xi''an Jiaotong University Health Science Center, Xi''an, Shaanxi 710061, PR China;2. Department of Pharmacology and Toxicology in the Brody School of Medicine at East Carolina University, Greenville, NC, USA;3. Research Center, Stomatological Hospital, Xi''an Jiaotong University Health Science Center, Xi''an, Shaanxi 710004, PR China;4. Department of Neural and Pain Sciences, University of Maryland Dental School, 650 West, Baltimore Street, Baltimore, MD 21201, USA;1. Surgical Research Laboratory, Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;2. Department of Experimental Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands;3. Department of Plasma Proteins, Sanquin Research, Amsterdam, The Netherlands;2. Department of Animal Science, Iwate University, Morioka, Iwate, Japan;3. Asahi Kasei Pharma Corporation, Shizuoka, Japan;4. Department of Symbiotic Systems Science and Technology, Graduate School of Symbiotic Systems Science and Technology, Fukushima University, Fukushima, Japan;5. Division of Applied Bioscience, Hokkaido University, Sapporo, Hokkaido, Japan |
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| Abstract: | Presently herbal medicines are being used by about 80% of the world population for primary health care as they stood the test of time for their safety, efficacy, cultural acceptability and lesser side effects. The discovery of platelet activating factor antagonists (PAF antagonists) during these decades are going on with different framework, but the researchers led their efficiency in studying in vitro test models. Since it is assumed that PAF play a central role in etiology of many diseases in humans such as asthma, neuronal damage, migraine, cardiac diseases, inflammatory, headache etc. Present days instinctively occurring PAF antagonist exists as a specific grade of therapeutic agents for the humans against these and different diseases either laid hold of immunological or non-immunological types. Ginkgolide, cedrol and many other natural PAF antagonists such as andrographolide, α-bulnesene, cinchonine, piperine, kadsurenone, different Piper species' natural products and marine origin plants extracts or even crude drugs having PAF antagonist properties are being used currently against different inflammatory pathologies. This review is an attempt to summarize the data on PAF and action of natural PAF antagonists on it, which were evaluated by in vivo and in vitro assays. |
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