Serum osteocalcin in dairy cows: age-related changes and periparturient variation |
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| Authors: | Sato Reiichiro Onda Ken Ochiai Hideharu Iriki Tsunenori Yamazaki Yukio Wada Yasunori |
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| Institution: | aLaboratory of Internal Medicine 3, Azabu University School of Veterinary Medicine, 1-17-71 Fuchinobe, Sagamihara, Kanagawa 229-8501, Japan;bResearch Institute of Biosciences, Azabu University School of Veterinary Medicine, 1-17-71 Fuchinobe, Sagamihara, Kanagawa 229-8501, Japan;cLaboratory of Animal Nutrition, Azabu University School of Veterinary Medicine, 1-17-71 Fuchinobe, Sagamihara, Kanagawa 229-8501, Japan;dNishishunbetsu Veterinary Clinical Center, Nemuro Agricultural and Mutual Aid Association, Betsukai-cho, Nishishunbetsu, Hokkaido 088-2576, Japan |
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| Abstract: | We evaluated age-related changes in serum osteocalcin concentrations in non-periparturient cows and variations in serum osteocalcin concentration in periparturient primiparous and multiparous cows. The serum osteocalcin levels were evaluated in 144 non-periparturient Holstein dairy cows aged 11 days to 10 years; these levels were the highest in the youngest cows, appeared to steadily decrease with age until the time of the first calving, and were subsequently maintained at low levels. Between 14 days before calving and 21 days after calving, the serum osteocalcin levels were significantly higher in the primiparous cows than in the multiparous cows. A comparison between age-matched non-periparturient and periparturient cows showed that serum osteocalcin levels were significantly lowered during late gestation in both primiparous and multiparous cows. These results suggest that serum osteocalcin measurement might be useful for the detection of mineral imbalances at the time of parturition in cows. |
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| Keywords: | Bone metabolic marker Cow Hypocalcaemia Osteocalcin |
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