Four new phenanthrenes from Monomeria barbata Lindl |
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| Authors: | Minghui Yang Le Cai Zhigang Tai Xianghui Zeng Zhongtao Ding |
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| Institution: | 1. Key Laboratory of Medicinal Chemistry for Nature Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China;2. Department of Biochemistry, Dali College, Dali 671000, PR China |
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| Abstract: | Three biphenanthrene compounds (1–3) and a triphenanthrene compound (4), together with six known biphenanthrene compounds (5–10), were isolated from the tubers of Monomeria barbata Lindl. Their structures were elucidated on the basis of extensive spectroscopic analysis (1D-, 2D-NMR, and HR-ESI-MS). These four new compounds were tested in vitro for the cytotoxic activity against liver carcinoma (HepG-2), promyelocytic leukaemia (HL60), ovarian carcinoma (Skov-3) and epidermoid carcinoma (A431) cancer cell lines and the antioxidant activity in DPPH radical scavenging. Compounds 1–4 exhibited significant cytotoxic activity against HepG-2 and HL60 cell lines, and potent antioxidant activity in DPPH radical scavenging. |
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| Keywords: | Monomeria barbata Biphenanthrene Triphenanthrene Cytotoxic activity Antioxidant activity |
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