Gastric absorption of a pesticide (1-naphthyl N-methylcarbamate) in the fasted rat |
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| Authors: | Howard H Casper Jerome C Pekas WE Dinusson |
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| Institution: | 1. Department of Animal Science, North Dakota State University Fargo, North Dakota 58102 USA |
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| Abstract: | The gastric absorption of 1-naphthyl-1-14C]N-methylcarbamate (radiolabeled carbaryl) administered intragastrically (7.5 μmoles/kg body wt) to fasted, anesthetized female rats was investigated by measurement of 14C absorption and by identification of the radiolabeled constituents in the portal blood. At 22 and 67 min after dosing, 52.6 ± 14.1% (n = 3) and 81.7 ± 15.7% (n = 3), respectively, of the 14C was absorbed from the stomachs (ligated pylori) of rats with intact portal circulation. In another experiment, 69.1 ± 25.9% (n = 3) of the 14C was absorbed from the rat stomachs (ligated pylorus and esophagus) during 66.0 ± 1.0 min of total portal blood collection (via an in vivo perfusion technique). The radiolabeled material in the collected portal blood accounted for 97.2 ± 1.9% (n = 3) of the 14C absorbed from rat stomachs. On the basis of thin-layer chromatography, gas chromatography, and infrared spectroscopy, 89.3% of the radiolabeled material in the collected portal blood was 1-naphthyl-1-14C]N-methylcarbamate. |
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