猪细小病毒病毒样颗粒研究进展 |
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引用本文: | 杜毅超,吴健敏,刘金凤.猪细小病毒病毒样颗粒研究进展[J].动物医学进展,2016(7):71-75. |
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作者姓名: | 杜毅超 吴健敏 刘金凤 |
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作者单位: | 1. 广西大学动物科学技术学院,广西南宁 530004; 广西兽医研究所动物疫病病原学与诊断重点实验室,广西南宁 530001;2. 广西兽医研究所动物疫病病原学与诊断重点实验室,广西南宁,530001 |
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基金项目: | 广西科技合作与交流计划项目(桂科合14125008-2-6),广西自然基金项目(2014GXNSFAA118120),广西重点实验室建设项目(14-045-31-A-5) |
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摘 要: | 猪细小病毒(PPV)是引起母猪繁殖障碍和仔猪死亡的主要病原,疫苗免疫预防是控制该病的主要手段。由于对生物安全的担心,目前国内使用的疫苗仍以灭活苗为主。病毒样颗粒(VLPs)疫苗以其安全性高、免疫原性好成为各类病毒疫苗研究的热门方向。猪细小病毒病毒样颗粒(PPV-VLPs)是不含PPV DNA的空衣壳结构,由PPV VP2结构蛋白体外自行组装形成,形态上与天然病毒粒子相似,具有很强的免疫原性和生物学活性。论文就VLPs疫苗的免疫机制及PPV-VLPs的组装及其在国内外的研究进行综述,为PPV-VLPs研究提供参考。
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关 键 词: | 猪细小病毒 VP2 病毒样颗粒 |
Progress on Porcine Parvovirus Virus-like Particles |
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Abstract: | Porcine parvovirus(PPV)is a main pathogen that causes serious reproductive disease of swine and death of piglets,and vaccination is one of the major measures.Due to bio-safety concern,the inactivated vac-cine was mainly used at home.Virus-like particles(VLPs)has the advantages of higher security and immu-nogenicity,it has become one of the hottest direction of virus vaccine research.Porcine parvovirus virus-like particles(PPV-VLPs)are empty capsid particles without PPV DNA,which are self-assembled by VP2 structural protein and are analogous to natural virus particles in morphology,and it has very strong bioac-tivity and immunogenicity.To provide the reference for the research of PPV-VLPs,this article reviewed im-mune mechanism of VLP-based vaccines and self-assembling of PPV-VLPs in the domestic and overseas. |
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Keywords: | Porcine parvovirus VP2 virus-like particle |
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