| 阿魏酸对ob/ob小鼠脂肪沉积及腹脂脂肪酸组成的影响 |
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| 引用本文： | 潘奕鸥,王薇薇,李爱科,张卫卫,韩四海,刘建学.阿魏酸对ob/ob小鼠脂肪沉积及腹脂脂肪酸组成的影响[J].动物营养学报,2016(7):2140-2146. |
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| 作者姓名： | 潘奕鸥 王薇薇 李爱科 张卫卫 韩四海 刘建学 |
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| 作者单位： | 1. 河南科技大学食品与生物工程学院，洛阳 471023; 国家粮食局科学研究院，北京 100037; 河南省食品原料工程技术研究中心，洛阳 471023;2. 国家粮食局科学研究院,北京,100037;3. 河南科技大学食品与生物工程学院,洛阳,471023;4. 河南科技大学食品与生物工程学院，洛阳 471023; 河南省食品原料工程技术研究中心，洛阳 471023 |
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| 基金项目： | 公益性(粮食)行业专项“粮油营养健康特性研究与基础参数数据库的构建”(201313011-6)；河南省重点攻关项目“农产品加工副产物的高效增值和循环利用关键技术研究”(142102310262) |
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| 摘 要： | 本试验旨在研究阿魏酸对ob/ob小鼠脂肪沉积和腹脂脂肪酸组成的影响。选取5周龄的雄性ob/ob小鼠30只,随机分为3组(n=10),分别饲喂在基础饲粮中添加0(对照组)、0.25%和0.50%阿魏酸的试验饲粮,试验期9周。结果表明:与对照组相比,饲粮中添加0.25%和0.50%的阿魏酸显著降低了ob/ob小鼠的总增重、腹脂率(P0.05),显著降低了血清甘油三酯及肝脏甘油三酯和总胆固醇水平(P0.05),减少了肝脏脂滴积累,显著降低了腹脂中棕榈油酸和油酸的含量(P0.05),显著降低了腹脂中棕榈油酸/棕榈酸和油酸/硬脂酸(P0.05)。由此得出,阿魏酸可以抑制ob/ob小鼠的脂肪沉积,改善其腹脂脂肪酸组成,减重降脂效果明显。
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| 关 键 词： | 阿魏酸 ob/ob小鼠 肥胖 脂肪沉积 脂肪酸组成 |
Effects of Ferulic Acid on Lipid Deposition and Fatty Acid Composition in Abdominal Lipid of ob/ob Mice |
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| Abstract: | This experiment was conducted to study the effects of ferulic acid ( FA) on lipid deposition and fatty acid composition in abdominal lipid of ob/ob mice. A total of 30 male ob/ob mice at 5 weeks old were ran?domly divided into 3 groups ( n=10) . ob/ob mice in the 3 groups were fed the basal diets supplemented with 0 ( control group ) , 0. 25% and 0. 50% FA, respectively. The experiment lasted for 9 weeks. The results showed that compared with control group, FA significantly reduced the total weight gain and abdomen fat per?centage ( P<0.05) , significantly lessened the serum TG and liver TG and TC levels ( P<0.05) , attenuated ac?cumulation of lipid droplet, significantly suppressed the contents of palmitoleic acid and oleic acid in abdominal lipid(P<0.05), and significantly decreased the desaturation indexes?palmitoleic acid/palmitic acid and oleic acid/ stearic acid in abdominal lipid ( P<0.05) . It is concluded that FA can inhibit the lipid deposition and a?meliorate the fatty acid composition in abdominal lipid, and the weight?reducing and lipid?lowering effect is ob?vious. |
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| Keywords: | ferulic acid ob/ob mice obesity lipid deposition fatty acid composition |
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