| 奥美拉唑联合大剂量去甲肾上腺素对上消化道大出血迅速止血的效果观察 |
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| 引用本文： | 关彩平.奥美拉唑联合大剂量去甲肾上腺素对上消化道大出血迅速止血的效果观察[J].湛江医学院学报,2001,19(1):26-28. |
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| 作者姓名： | 关彩平 |
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| 作者单位： | 广东湛江南油医院!广东湛江524057 |
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| 摘 要： | 目的 :探讨一种对上消化道出血安全有效的快速止血方法。方法 :87例患者随机分 A、B两组 :A组 (n=47)用奥美拉唑 40 mg静注 ,每 12 h一次 ,连用 3d后改为口服 ;同时口服 0 .4g/ L 去甲肾上腺素盐水 2 0 m L,每 1h一次 ,连用 6次 ,然后根据出血情况调整给药时间 (每 2～ 4h一次 ) ,止血后停用 ;B组 (n=40 ) ,奥美拉唑用法同 A组 ,不用去甲肾上腺素。结果 :A组的止血效果明显优于 B组 ,差异有显著性 (H c=5 .85 2 P<0 .0 5 ) ;A组的快速止血率 (显效率 )和总有效率均明显高于 B组 (6 8.1% vs45 .0 % ,93.6 % ,vs77.5 % ) ,差异均有显著性 (P<0 .0 5 )。未见明显副作用 ,治疗 12 h后查胃镜均未发现有胃粘膜坏死现象。结论 :静注奥美拉唑联合口服大剂量去甲肾上腺素对上消化道大出血有快速止血作用 ,适用于广大基层医院和院前急救
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| 关 键 词： | 消化性溃汤出血 止血 奥美拉唑 去甲肾上腺素 |
| 文章编号： | 1005-4057（2001）-01-0026-03 |
| 修稿时间： | 2000年9月21日 |
Effect of intravenous omeprazole and high dosage of oral noradrenaline on rapid hemostasis for upper gastrointestinal hemorrhage |
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| GUAN Cai-ping.Effect of intravenous omeprazole and high dosage of oral noradrenaline on rapid hemostasis for upper gastrointestinal hemorrhage[J].Journal of Guangdong Medical College,2001,19(1):26-28. |
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| Authors: | GUAN Cai-ping |
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| Abstract: | Objective:To probe into a safe effective rapid hemostasia for upper gastrointestinal hemorrhage(UGIH).Methods:87 patients with UGIH were randomly divided into two groups(Group A and Group B).The patients in Group A( n =47)were intravenously given omeprazole of 40 mg every 12 hours combined with 0.4 g/L noradrenaline 20 mL orally every hour within initial 6 hours,followed with every 2 to 4 hours according to hemorrhagic conditions.Omeprazole was orally given instead after three days.Once hemostasis could be gained,noradrenaline was discontinued.The patients in Group B( n =40)received only omeprazole as its usage and dosage as in Group A.Results:The efficacy of hemosatasis in Group A was significantly better than that in Group B( Hc =5.852 P <0.05).The rate of rapid hemostasis (within 12 hours)and total effective rate were substantially greater in Group A compared with those in Group B(68.1% vs 45.0%,93.6% vs 77.5%,respectively, P <0.05).No obvious side effects were observed.Gastric mucosa necrosis under gastroscopy did not occur in Group A when high dosage of noradrenaline had been orally given for 12 hours.Conclusion:Intravenous omeprazole combined with high dosage of orally noradrenaline may play rapid hemostatic role in upper gastrointestinal hemorrhage and suits to critical hemostasis of UGIH at local hospital before the victims will be taken to medical center. |
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| Keywords: | upper gastrointestinal hemorrhage hemostasia omeprazole noradrenaline |
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