| 磺胺二甲基嘧啶(SM2)在鸡体内代谢动力学及其生物利用度的研究 |
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| 引用本文： | 谢联金,冯士强,刘金风.磺胺二甲基嘧啶(SM2)在鸡体内代谢动力学及其生物利用度的研究[J].中国农业大学学报,1986(1):111-117. |
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| 作者姓名： | 谢联金 冯士强 刘金风 |
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| 作者单位： | A STUDY ON PHARMACOKINETICS OF SULFAMETHAZINE IN CHICKENS |
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| 摘 要： | 本文报告 SM_2在育成鸡体内的药代动力学过程及其生物利用度的研究。口服 SM_2(100毫克/公斤)胶囊剂后,药一时曲线呈单指数下降,符合开放式一室模型,并计算药代动力学参数 t_(1/2Ka),t_(1/2β),t_(CP)(they),t_P,AUC,Cmax 分别为0.85±0.081小时,11.92±2.16小时,11.33±0.55小时,3.48±0.27小时,1.55±0.14毫克/毫升·小时,74.0±4.1微克/毫升。交叉试验,快速静脉推注同剂量 SM_2时。药一时曲线呈双指数曲线下降,理论值与实测值极为吻合。静注后t_(1/2B),T_(CP),V_d,AUC 分别为10.65±1.20小时,14.43±1.25小时,778±32毫升/公斤,1.97±0.16毫克/毫升·小时。口服 SM_2胶囊剂的生物利用度 F(%)=77.83±2.16。
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| 关 键 词： | 生物利用度 指数曲线 胶囊剂 动物血药浓度 静脉推注 药代动力学参数 开放式 |
A STUDY ON PHARMACOKINETICS OF SULFAMETHAZINE IN CHICKENS |
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| Xie Lianiin Feng Shiqiang Liu Jinfeng.A STUDY ON PHARMACOKINETICS OF SULFAMETHAZINE IN CHICKENS[J].Journal of China Agricultural University,1986(1):111-117. |
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| Authors: | Xie Lianiin Feng Shiqiang Liu Jinfeng |
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| Abstract: | This paper reports on the study of the dynamic relationship,in terms of time,in the process of sulfamethazine and sodium sulfameth- azine in four-and-half-month-old chicken's body,each single dosage being 100mg./kg.of body weight. 1.The concentration of unchanged sulfamethazine in plasma of the chikens administered orally with capsules was fitted to a lineal pharm- acokinetic model in which sulfamethazine itself obeyed one-compartm- ent pharmacokinetics.The average rate constant for overall elimination of s... |
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