Classical swine fever virus infection modulates serum levels of INF-α, IL-8 and TNF-α in 6-month-old pigs |
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| Institution: | 1. Section for Virology, National Veterinary Institute, Technical University of Denmark, Lindholm, DK-4771 Kalvehave, Denmark;2. Section for Molecular Disease Biology, Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Dyrlaegevej 88, 1, DK-1870 Frederiksberg C, Denmark;1. Department of Biochemistry and Molecular Biology, Federal University of Viçosa, Viçosa, MG, Brazil;2. Department of Microbiology, Institute of Biotechnology Applied to Agriculture (BIOAGRO), Federal University of Viçosa, Viçosa, MG, Brazil;4. Department of Phytopatology, Federal University of Viçosa, Viçosa, MG, Brazil;1. Agri-food and Biosciences Institute (AFBI), Stoney Road, BT4 3SD Belfast, UK;2. Public Health England (PHE), 61 Colindale Avenue, NW9 5EQ London, UK;3. Animal Health and Plant Agency (APHA), Kendal Road, Shrewsbury, Shropshire SY1 4HD, UK;1. Institute of Veterinary Animal and Biomedical Sciences, Massey University, Private Bag 11-222 Palmerston North, New Zealand;2. Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, Utrecht, The Netherlands;1. Anses, Laboratoire de Sophia-Antipolis, Unité pathologie des ruminants, 105 Route des Chappes - B.P. 111, 06902 Sophia-Antipolis Cedex, France;2. Laboratoire Départemental Vétérinaire et d’Hygiène Alimentaire des Hautes-Alpes, Rue des Silos 5, B.P. 63, F-05602 Gap Cedex, France;3. Cabinet Vétérinaire, Barcelonette, France;4. Coopérative de l’Agneau de Haute-Provence, Digne Les Bains, France;5. Research Unit in Epidemiology and Risk Analysis Applied to Veterinary Sciences, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine, University of Liège, Boulevard de Colonster, 20, B42, B-4000 Liège, Belgium;1. School of Veterinary Science, Massey University, Private Bag 11222, Palmerston North 4442, New Zealand;2. Animal Health Laboratory, Ministry of Primary Industries, Wallaceville, New Zealand;3. EpiCentre, School of Veterinary Science, Massey University, Private Bag 11222, Palmerston North, 4442, New Zealand;4. AgResearch, Invermay Agricultural Centre, Private Bag 50034, Mosgiel, 9053, New Zealand |
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| Abstract: | Several studies have highlighted the important role of cytokines in disease development of classical swine fever virus (CSFV) infection. In the present study, we examined the kinetics of 7 porcine cytokines in serum from pigs infected with 3 different CSFV strains. Based on the clinical picture in 6-month-old Danish pigs, the strains used for inoculation were classified as being of low (Bergen), low to moderate (Eystrup) and moderate to high (Lithuania) virulence. The cytokines interferon-alpha (INF-α), interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-α) showed increased levels after CSFV infection with more or less comparable course in the 3 groups. However, the cytokine level peaked with a 2–3 days delay in pigs infected with the low virulent strain compared to those infected with a moderately or highly virulent strain. These findings may indicate that INF-α, IL-8 and TNF-α are involved in the immune response during CSFV infection with strains of different virulence. |
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| Keywords: | Cytokines Pigs Classical swine fever virus Pathogenesis Virulence Pestivirus |
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