| 葡聚糖硫酸钠诱导的小鼠肠炎中骨质丢失的分析 |
| |
| 引用本文： | 魏凡华,胡志华.葡聚糖硫酸钠诱导的小鼠肠炎中骨质丢失的分析[J].农业科学研究,2014(4):39-41. |
| |
| 作者姓名： | 魏凡华 胡志华 |
| |
| 作者单位： | 1. 宁夏大学 农学院,宁夏 银川,750021
2. 金陵科技学院 动物科学与技术学院,江苏 南京,210038 |
| |
| 摘 要： | 建立小鼠葡聚糖硫酸钠肠炎（DSS）模型，并分析肠炎小鼠中骨质丢失的发生情况.C57BL/6小鼠口服DSS溶液2周以建立肠炎模型，第1周饮用2% DSS溶液，第2周饮用1% DSS溶液.饮用蒸馏水的C57BL/6小鼠作为对照.记录每组小鼠体质量变化，观察粪便和血便状况，μCT分析股骨骨质丢失的情况.结果表明DSS处理组小鼠和对照组相比，出现了明显的骨质丢失，骨量减少，骨小梁数目下降.说明DSS诱导的小鼠肠炎模型可以作为研究肠炎引发骨质丢失的良好模型.
|
| 关 键 词： | 肠炎 葡聚糖硫酸钠 骨质丢失 小鼠 |
Dextran sodium sulfate-induced colitis leads to bone loss in mice |
| |
| Wei Fanhua,Hu Zhihua.Dextran sodium sulfate-induced colitis leads to bone loss in mice[J].Journal of Agricultural Sciences,2014(4):39-41. |
| |
| Authors: | Wei Fanhua Hu Zhihua |
| |
| Institution: | Wei Fanhua, Hu Zhihua (1. The Agricultural School, Ningxia University, Yinchuan 750021 ,China; 2. College of Animal Science and Technology, Jinling Insititute of Technology, Nanjing 210038,China) |
| |
| Abstract: | To establish a colitis model induced by dextran sodium sulfate （DSS） and analyzed bone loss in colitic mice. Colitis was induced by administration of DSS solution for 2 weeks, 2%DSS and 1%DSS solution was administrated on the first week and second week, respectively. Body weight, stool and blood score of each group mice was recorded, and femoral bone loss were examined by micro computed tomography （μCT）. The results demonstrate that DSS-treated mice exhibited a lower bone mass and decreased trabecular numbers as compared with the controls. Collectively, DSS-induced colitis model can be used to study pharmacological interventions for bone loss in mice. |
| |
| Keywords: | colitis dextran sodium sulfate bone loss mice |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
