| 牛传染性鼻气管炎病毒LNM株致弱疫苗免疫效力的研究 |
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| 引用本文： | 郭利,冷雪,张淑琴,苗立光,赵炳武,武华.牛传染性鼻气管炎病毒LNM株致弱疫苗免疫效力的研究[J].中国预防兽医学报,2011,33(2). |
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| 作者姓名： | 郭利 冷雪 张淑琴 苗立光 赵炳武 武华 |
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| 作者单位： | 中国农业科学院特产研究所,吉林,吉林,132109 |
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| 基金项目： | 牛羊重大疫病防控技术研究与产业化(200803018) |
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| 摘 要： | 为检测牛传染性鼻气管炎病毒(IBRV)抗体在免疫牛体内的产生及其消长规律,评价IBRV LNM株致弱疫苗的保护效力,并确定免疫持续期,本实验对免疫试验组牛每头颈部肌肉接种制备的IBRV LNM株致弱疫苗104.5 TCID50/mL,监测血清抗体效价,进行免疫期的确定。在疫苗免疫后的6个月、9个月和12个月分别抽取3头免疫组和两头对照组牛采用IBRV-LN01/08强毒株进行攻毒试验,每头牛的攻毒剂量为107.0 TCID50/mL。结果显示疫苗免疫后12个月时,中和抗体效价仍维持在1∶11以上。攻毒结果显示3个时间点强毒攻击后,疫苗对免疫牛均具有良好的保护力。研究表明IBRV弱毒疫苗可有效地保护免疫牛抵抗IBRV强毒株的攻毒,其免疫持续期最少为12个月。
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| 关 键 词： | 牛传染性鼻气管炎病毒 弱毒活疫苗 效力 免疫持续期 |
The efficacy of the attenuated infectious bovine rhinotracheitis virus LNM vaccine strain |
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| GUO Li,LENG Xue,ZHANG Shu-qin,MIAO Li-guang,ZHAO Bing-wu,WU Hua.The efficacy of the attenuated infectious bovine rhinotracheitis virus LNM vaccine strain[J].Chinese Journal of Preventive Veterinary Medicine,2011,33(2). |
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| Authors: | GUO Li LENG Xue ZHANG Shu-qin MIAO Li-guang ZHAO Bing-wu WU Hua |
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| Institution: | GUO Li,LENG Xue,ZHANG Shu-qin,MIAO Li-guang,ZHAO Bing-wu,WU Hua*(Institute of Special Wild Economic Animal and Plant Science,Chinese Academy of Agricultural Sciences,Jilin 132109,China) |
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| Abstract: | This study was designed to evalutate neutralizing(SN) antibodies against infectious bovine rhinotracheitis virus(IBRV) in the calves vaccinated with the attenuated IBRV vaccine.A total of 15 healthy calves at weaning were randomly divided into two groups,with 9 calves in vaccinate group and 6 in control group.The attenuated IBRV LNM vaccine strain was administrated via intramuscular injection on the neck at a single dose of 1mL and challenged with a virulent IBRV-LN01/08 virus by nasal spray.The blood sampl... |
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| Keywords: | infectious bovine rhinotracheitis virus live attenuated vaccine efficacy duration of immunity |
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