A vaccine prepared from a non-pathogenic H5N1 influenza virus strain from the influenza virus library conferred protective immunity to chickens against the challenge with antigenically drifted highly pathogenic avian influenza virus |
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| Authors: | Samad Rozanah Asmah Abdul Nomura Naoki Tsuda Yoshimi Manzoor Rashid Kajihara Masahiro Tomabechi Daisuke Sasaki Takashi Kokumai Norihide Ohgitani Toshiaki Okamatsu Masatoshi Takada Ayato Sakoda Yoshihiro Kida Hiroshi |
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| Institution: | Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan. |
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| Abstract: | Inactivated influenza virus vaccine prepared from a non-pathogenic influenza virus strain A/duck/Hokkaido/Vac-1/2004 (H5N1) from the virus library conferred protective immunity to chickens against the challenge of antigenically drifted highly pathogenic avian influenza virus (HPAIV), A/whooper swan/Hokkaido/1/2008 (H5N1). The efficacy of the vaccine was comparable to that prepared from genetically modified HPAIV strain deltaRRRRK rg-A/ whooper swan/Mongolia/3/2005 (H5N1), which is more antigenically related to the challenge virus strain, in chickens. |
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