| 溴氰菊酯对麦穗鱼谷胱甘肽S-转移酶(GSTs)的影响 |
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| 引用本文： | 尹晓辉,林荣华,陶传江,姜辉,赵震宇,高希武.溴氰菊酯对麦穗鱼谷胱甘肽S-转移酶(GSTs)的影响[J].农药学学报,2005,7(3):249-253. |
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| 作者姓名： | 尹晓辉 林荣华 陶传江 姜辉 赵震宇 高希武 |
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| 作者单位： | 1.农业部农药检定所 生物技术研究测试中心,北京 100026 |
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| 基金项目： | “十五”国家科技攻关项目（2001BA509B08）. |
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| 摘 要： | 研究了溴氰菊酯不同浓度、不同处理时间对麦穗鱼体内谷胱甘肽S-转移酶(GSTs)活性的影响,同时测定了麦穗鱼不同组织中谷胱甘肽S-转移酶对低浓度溴氰菊酯处理的反应特点。结果表明,处理48 h后,高浓度(0.009 mg/L)组对肝中GSTs活性的抑制率达到43.7％,对鳃中GSTs活性的抑制率达54.3％;而低浓度组(0.001 mg/L)对鳃中GSTs活性有一定的诱导作用。亚致死剂量的溴氰菊酯(3.0×10-4mg/L)处理96 h后,对卵巢的诱导活性最高,其GSTs活性是对照的2.43倍,但对肝、鳃、肾、肠的诱导作用均较低。溴氰菊酯对麦穗鱼不同组织GSTs活性诱导的时间效应和强度不同。
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| 关 键 词： | 溴氰菊酯 谷胱甘肽S-转移酶(GSTs) 麦穗鱼 抑制作用 诱导作用 |
| 文章编号： | 1008-7303（2005）03-0249-05 |
| 收稿时间： | 2005-03-07 |
| 修稿时间： | 2005-04-28 |
The Effect of Deltamethrin on Specific Activities of GSTs in Pseudorasbora parva |
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| YIN Xiao-hui,LIN Rong-hu,TAO Chuan-jiang,JIANG hui,ZHAO Zhen-yu and GAO Xi-wu.The Effect of Deltamethrin on Specific Activities of GSTs in Pseudorasbora parva[J].Chinese Journal of Pesticide Science,2005,7(3):249-253. |
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| Authors: | YIN Xiao-hui LIN Rong-hu TAO Chuan-jiang JIANG hui ZHAO Zhen-yu and GAO Xi-wu |
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| Institution: | 1.The Center for Agrochemicals Biological and Environmental Technology,Insititute for the Control of Agrochemicals, Ministry of Agriculture, P.R. China,Beijing 100026,China2.Department of Insect, China Agricultural University, Beijing 100094,China3.College of Agriculture, Xinjiang Agricultural University, Urmqi 830000,China |
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| Abstract: | The topmouth gudgeon (Pseudorasbora parva) was exposed to different concentrations of deltamethrin in statics for 96 h, and the effects of deltamethrin on the specific activities of glutathione S-transferase (GSTs) were evaluated at the end of 6 h, 12 h, 24 h, 36 h, 48 h, 72 h, and 96 h pesticide exposure. The specific activities of GSTs were measured in supernatant after centrifugation (10 000 g) of homogenation from liver, gill, kidney, muscle and ovary of topmouth gudgeon. The results indicated that the specific activities of GSTs were significantly inhibited by deltamethrin in high concentrat ions(0.009 mg/L), and the specific activities of GSTs were reduced 43.7％in liver and 54.3% in gill at the end of 48 h. Under lower concentrations(0.001 mg/L),the specific activities of GSTs in gill were induced, but not significantly. The specific GSTs activities of ovary in tomouth gudgeon, at the end of 96 h exposure to 3.0×10-4 mg/L deltamethrin, were 143% increased compare with that of control. The levels of induction were variable in different organ, and changed with exposed time. Therefore, future studies should be carried out to understand the underlying mechanisms involved in longterm toxicity profile of deltamethrin. |
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| Keywords: | deltamethrin Pseudorasbora parva glutathion S-transferase(GSTs) inhibition (induction) |
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