Long-range-projecting GABAergic neurons modulate inhibition in hippocampus and entorhinal cortex |
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| Authors: | Melzer Sarah Michael Magdalena Caputi Antonio Eliava Marina Fuchs Elke C Whittington Miles A Monyer Hannah |
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| Institution: | Department of Clinical Neurobiology of the Medical Faculty of Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg, Germany. |
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| Abstract: | The hippocampus and entorhinal cortex play a pivotal role in spatial learning and memory. The two forebrain regions are highly interconnected via excitatory pathways. Using optogenetic tools, we identified and characterized long-range γ-aminobutyric acid-releasing (GABAergic) neurons that provide a bidirectional hippocampal-entorhinal inhibitory connectivity and preferentially target GABAergic interneurons. Activation of long-range GABAergic axons enhances sub- and suprathreshold rhythmic theta activity of postsynaptic neurons in the target areas. |
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