The DNA of an IPV strain of bovid herpesvirus 1 in sacral ganglia during latency after intravaginal infection |
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| Authors: | Mathias Ackermann Robert Wyler |
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| Institution: | Institute of Virology, University of Zürich, Winterhurerstr. 266A, 8057 Zürich Switzerland |
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| Abstract: | Two calves were inoculated intravaginally with a strain of bovid herpesvirus type 1 (BHV-1, IBR/IPV) isolated from a cow with infectious pustular vulvovaginits (IPV). The animals were killed during a latent stage of infection as characterized by seroconversion, absence of virus shedding and recrudescence of virus shedding after dexamethsone treatment.IPV-virus DNA was detected in 9 out of 20 sacral ganglia of the 2 calves. Of the sections, 7.2% (n = 250) contained 1 cell with IPV-virus DNA, which was restricted to the nucleus of neurons. In agreement with findings on herpes simplex virus infections, the viral DNA of BHV-1 is harbored in the local sensory ganglia.Virological and serological implications of the latent IPV infection are discussed. |
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