| 百草枯引起胎鼠动脉管收缩与内皮素及其受体的关系研究 |
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| 引用本文： | 沈明浩,李大军,庄英男,陈萍,任大勇.百草枯引起胎鼠动脉管收缩与内皮素及其受体的关系研究[J].中国畜牧杂志,2006,42(11):19-22. |
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| 作者姓名： | 沈明浩 李大军 庄英男 陈萍 任大勇 |
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| 作者单位： | 吉林农业大学食品工程学院毒理学研究室,吉林,长春,130118 |
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| 摘 要： | 本文研究了百草枯对胎儿动脉管的毒性作用机理。取妊娠21d大鼠随机分成5组,在不同时间皮下注射25mg/kg百草枯,观察胎儿动脉管收缩情况;取妊娠21d大鼠随机分成4组,试验第1组母体皮下注射25mg/kg百草枯,第2组和第3组胎儿分别注射生理盐水和TAK-044后,母体皮下注射25mg/kg百草枯,观察胎儿动脉管收缩情况;用BQ-123代替TAK-044重复上述操作。结果表明:百草枯对妊娠末期胎儿动脉管具有毒性作用;由百草枯引起的胎儿动脉管收缩与ET有关,且以ETA受体作为媒介参与动脉管收缩。
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| 关 键 词： | 畜牧、兽医科学基础学科 百草枯 动脉管 胚胎毒性 大鼠 |
| 文章编号： | 0258-7033(2006)11-0019-04 |
| 收稿时间： | 2006-02-13 |
| 修稿时间： | 2006-03-17 |
The Relationship between Contraction of Arterial Ductus of Fetuses Induced by Paraquat and Endothelin and Its Receptor |
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| SHEN Ming-hao,LI Da-jun,ZHANG Ying-nan,CHEN Ping,REN Da-yong.The Relationship between Contraction of Arterial Ductus of Fetuses Induced by Paraquat and Endothelin and Its Receptor[J].Chinese Journal of Animal Science,2006,42(11):19-22. |
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| Authors: | SHEN Ming-hao LI Da-jun ZHANG Ying-nan CHEN Ping REN Da-yong |
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| Institution: | Toxicology Institute of Food Institute of Technology, Jilin Agricultural University, Jilin Changchun 130118, China |
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| Abstract: | The mechanism of toxic effects of paraquat on arterial dutus of rat fetus was studied in this paper. Twenty gravid female Wistar rats of 21 days were divided randomly into five groups, the pregnant rats in each group were hypodermic injected with paraquat at the dose of 25mg/kg at different time. Fetuses were obtained for observing the contraction of dutus arteriosus; Sixteen gravid female Wistar rats of 21 days were divided randomly into four groups, group1, the mother' body were hypodermic injected with paraquat at the dose of 25 mg/kg, group 2 and 3 were respectively injected with physiological saline and TAK-044, then the mother's bodies were hypodermic injected with paraqut at the dose of 25 mg/kg, the fetuses were used for observing the contraction of dutus arteriosusl, repeating this step with BQ-123 in steady of TAK-044. The results showed that paraquat has toxic effects on the cantraction of fetus's dutus arteriosus in the final phase of pregnant; The contraction of dutus arteriosus induced by paraquat is related to ET and ETA receptor participates the contraction of dutus arterious as medium. |
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| Keywords: | basal disciplines of animal and veterinary science paraquat dutus arteriousus embryo's toxicity rat |
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