An Improved Synthesis of 7, 8-Epoxy-1,3,11-cembratriene- 15R(α), 16-diol,a Cembranoid of Marine Origin with a Potent Cancer Chemopreventive Activity |
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| Authors: | Hesham Fahmy Sherief I Khalifa Takao Konoshima Jordan K Zjawiony |
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| Abstract: | An effective method for the synthesis of 7,8-epoxy-1,3,11-cembratriene- 15R(α),16-diol and its in vitro Epstein-Barr Virus Early Antigen (EBV-EA) Activation Chemopreventive Assay are reported. This semisynthetic product is a new cembranoid with a potent tumor inhibitory activity that is expected to be a lead compound for a new class of chemopreventive agents of marine origin. |
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| Keywords: | cancer chemoprevention cembranoids sarcophine sarcophytol A EBV-EA activation |
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