甲砜霉素在鲤鱼中的药代动力学研究 |
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作者姓名: | 潘明轩 李兆新 邢丽红 孙晓杰 彭吉星 董 晓 |
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作者单位: | 中国水产科学研究院黄海水产研究所;上海海洋大学食品学院;农业农村部水产品质量安全风险评估实验室 |
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摘 要: | 本实验在(26±2)℃的养殖水温下,采用高效液相色谱–串联质谱法(HPLC-MS/MS)研究了以30 mg/(kg·bw)的剂量对鲤鱼(Cyprinus carpio)进行单次投喂药饵后甲砜霉素(Thiamphenicol,TAP)在鲤鱼体内的药物代谢动力学。通过DAS 2.0动力学软件分析TAP在鲤鱼体内的药–时数据,结果表明符合一级吸收二室模型。TAP在肌肉、肾脏、肝脏、鱼皮、鳃、脾脏和血浆各组织的药物达峰时间(T_(peak))分别为16、2、16、8、0、2和16 h,达峰浓度(C_(max))分别为15.6、35.3、12.4、9.0、33.0、11.6 mg/kg和21.0 mg/L;药–时曲线下面积(AUC)分别为1084.5、1578.1、777.3、541.1、0.1、478.1 mg/(kg·h)和485.1 mg/(L·h),消除半衰期(t_(1/2β))分别为11.4、100.2、54.2、41.1、69.5、38.0和71.9 h。TAP在鲤鱼体内各组织的分布和消除速率相差较大;在肾脏中的药物达峰时间短且达峰浓度高于其他组织,其消除半衰期也明显高于其他组织,推测肾脏是鲤鱼体内TAP蓄积和代谢的主要器官。按照农业部《动物性食品中兽药最高残留限量》文件规定,TAP在水产动物中最高残留限量(MRL)不得高于50μg/kg,本研究中,肌肉、肾脏、肝脏、鱼皮、脾脏和血浆的TAP残留量低于MRL的时间分别从第16、16、12、12、12、10和12天开始,将肌肉和肾脏作为TAP药物残留的靶组织,建议休药期不得低于16 d。
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关 键 词: | 甲砜霉素 代谢残留 鲤鱼 药代动力学 |
收稿时间: | 2017/7/5 0:00:00 |
修稿时间: | 2017/8/14 0:00:00 |
Drug Pharmacokinetic Study of Thiamphenicol in Cyprinus carpio |
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Authors: | PAN Mingxuan LI Zhaoxin XING Lihong SUN Xiaojie PENG Jixing and DONG Xiao |
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Institution: | Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071;College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306;Laboratory of Quality & Safety Risk Assessment for Aquatic Products,Ministry of Agriculture and Rural Affairs, Qingdao 266071,Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071;Laboratory of Quality & Safety Risk Assessment for Aquatic Products,Ministry of Agriculture and Rural Affairs, Qingdao 266071,Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071;Laboratory of Quality & Safety Risk Assessment for Aquatic Products,Ministry of Agriculture and Rural Affairs, Qingdao 266071,Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071;Laboratory of Quality & Safety Risk Assessment for Aquatic Products,Ministry of Agriculture and Rural Affairs, Qingdao 266071,Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071;Laboratory of Quality & Safety Risk Assessment for Aquatic Products,Ministry of Agriculture and Rural Affairs, Qingdao 266071 and Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071;College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306;Laboratory of Quality & Safety Risk Assessment for Aquatic Products,Ministry of Agriculture and Rural Affairs, Qingdao 266071 |
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Abstract: | |
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Keywords: | Thiamphenicol Metabolic residue Carp Pharmacokinetics |
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