| 磺胺二甲嘧啶对小鼠亚慢性毒性、骨髓细胞微核及精子畸形的影响 |
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| 引用本文： | 魏星华,郑晓华,张田田,沈明浩.磺胺二甲嘧啶对小鼠亚慢性毒性、骨髓细胞微核及精子畸形的影响[J].中国畜牧兽医,2010,37(5):119-122. |
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| 作者姓名： | 魏星华 郑晓华 张田田 沈明浩 |
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| 作者单位： | （吉林农业大学食品科学与工程学院， 长春 130118） |
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| 基金项目： | 吉林省科技厅国际合作项目 |
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| 摘 要： | 试验选取昆明种小鼠,采用经口灌胃法,研究磺胺二甲嘧啶对小鼠亚慢性毒性、骨髓细胞微核和精子畸形的影响。结果显示,亚慢性毒性试验中,高、中剂量组小鼠体重与对照组和低剂量组差异极显著(P0.01);高剂量组雄性小鼠心脏的脏器系数与对照组和低剂量组差异显著(P0.05);高剂量组雄性小鼠肾脏的脏器系数显著低于对照组(P0.05),雌性小鼠肾脏的脏器数显著低于对照组与低剂量组(P0.05);小鼠骨髓细胞微核试验中高剂量组与空白对照组差异显著(P0.05),高、中、低剂量组间无显著差异;小鼠精子畸形试验中,高、中剂量组与空白对照组差异极显著(P0.01),低剂量组与空白对照组差异显著(P0.05),高剂量组与中、低剂量组差异显著(P0.05)。结果表明,高剂量的磺胺二甲嘧啶对小鼠的心脏和肾脏及微核发生率有一定影响;中剂量的磺胺二甲嘧啶对雌性小鼠的微核发生率具有一定影响;高、中、低剂量的磺胺二甲嘧啶对精子畸形率均具有一定影响。
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| 关 键 词： | 磺胺二甲嘧啶 亚慢性毒性 微核 精子畸形 |
Subchronic Toxicity, Bone Marrow Cell Micronucleus and Sperm Abnormality of Sulfamethazinum in Mice |
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| WEI Xing-hua,ZHENG Xiao-hua,ZHANG Tian-tian,SHEN Ming-hao.Subchronic Toxicity, Bone Marrow Cell Micronucleus and Sperm Abnormality of Sulfamethazinum in Mice[J].China Animal Husbandry & Veterinary Medicine,2010,37(5):119-122. |
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| Authors: | WEI Xing-hua ZHENG Xiao-hua ZHANG Tian-tian SHEN Ming-hao |
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| Institution: | (College of Food Science and Engineering,Jilin Agricultural University，Changchun 130118，China) |
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| Abstract: | Kunming mice were chosen to administer by intragastric administration in this study. We evaluated the effect of the Sulfamethazinum to subchronic toxicity, bone marrow cell micronucleus and spern abnormality on mice. In subchronic toxicity test, the difference of weight changes of mice in high dose group and middle dose group were lower obviously than the control group and the low dose group(P＜0.01). The organ coefficient of heart of the male mice in high dose gorup were lower obviously than the control group and the low dose group(P＜0.05).The organ coefficient of kidney of the male mice were lower obviously than the control group(P＜0.05). The organ coefficient of kidney of the female mice in high dose group were lower obviously than the control group and the low dose group(P＜0.05). In bone marrow cell micronucleus test, high dose Sulfamethazinum group had significant difference compared with blank control group(P＜0.05),but there were no significant difference in high, middle and low dose of Sulfamethazinum groups. And in sperm abnormality test. the high and middle dose groups had very significant higher rate than blank control group(P＜0.01), the low dose group had significant difference compared with blank control group(P＜0.05), the high dose group had significant higher than the middle and low dose group(P<0.05). The results indicated that the high dose of Sulfamethazinum group affected the heart, kidney and bone marrow cell micronucleus on mice, the middle dose of Sulfametazinum group had the influence on bone marrow cell micronucleus of the male mice, the high, middle and low dose of Sulfamethazinum groups had the effect on the sperm abnormality. |
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| Keywords: | Sulfamethazinum subchronic toxicity micronucleus sperm abnormality |
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