Novel Canine Tumour Suppressor Gene p53 Mutations in Cases of Skin and Mammary Neoplasms |
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| Authors: | Mayr B Reifinger M Alton K |
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| Institution: | (1) Institute for Animal Breeding and Genetics, Veterinary University, Veterinärplatz 1, A-1210 Vienna, Austria;(2) Institute for Pathology, Veterinary University, Veterinärplatz 1, A-1210 Vienna, Austria |
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| Abstract: | Exons 4 to 8 of the tumour suppressor gene p53 were analysed in 25 skin and 25 mammary tumours of 50 dogs. A 1 bp deletion (ACC AC) was detected in codon 89 in exon 4 in a squamous cell carcinoma. A missense mutation CGCCAC (argininehistidine) was present in codon 162 in exon 5 in a mammary adenocarcinoma. Moreover, a silent mutation occurred in codon 103 (serine) of exon 4 in a mammary adenoma. The somatic nature of the three mutations was demonstrated. |
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| Keywords: | dog gene mammary gland mutation p53 skin tumour |
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