| 2-(2-氨基噻唑-4-基)-(Z)-甲氧亚氨基乙酸酯的酰胺及亚胺衍生物的合成及抑菌活性 |
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| 引用本文： | 高涵莹,周思泓,师伟,乔柱,魏宁宁,周文明.2-(2-氨基噻唑-4-基)-(Z)-甲氧亚氨基乙酸酯的酰胺及亚胺衍生物的合成及抑菌活性[J].农药学学报,2011,13(3):228-232. |
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| 作者姓名： | 高涵莹 周思泓 师伟 乔柱 魏宁宁 周文明 |
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| 作者单位： | 1.西北农林科技大学理学院,陕西 杨凌 712100 |
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| 摘 要： | 以乙酰乙酸甲(乙)酯为原料,合成了2-(2-氨基噻唑-4-基)-(Z)-甲氧亚氨基乙酸酯的酰胺和亚胺两类共13个衍生物,其中10个化合物未见文献报道,所有化合物的结构均经核磁共振氢谱(1H NMR)、红外光谱(IR)和电喷雾电离质谱(ESI-MS)确证。初步杀菌活性测试结果表明,所有化合物在质量浓度200 mg/L下对6种供试植物病原菌均有不同程度的抑制作用,其中化合物 mk-1 在200 mg/L下对小麦赤霉病菌Fusarium graminearum的抑制率达81.4%。
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| 关 键 词： | 噻唑类化合物 甲氧亚胺基乙酸酯 合成 抑菌活性 |
| 收稿时间： | 2010/10/20 0:00:00 |
| 修稿时间： | 2010/11/24 0:00:00 |
Synthesis and fungicidal activity of amide and imine derivatives of 2-(2-aminothiazol-4-yl)-(Z) methoxyiminoacetate |
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| GAO Han-ying,ZHOU Si-hong,SHI Wei,QIAO Zhu,WEI Ning-ning and ZHOU Wen-ming.Synthesis and fungicidal activity of amide and imine derivatives of 2-(2-aminothiazol-4-yl)-(Z) methoxyiminoacetate[J].Chinese Journal of Pesticide Science,2011,13(3):228-232. |
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| Authors: | GAO Han-ying ZHOU Si-hong SHI Wei QIAO Zhu WEI Ning-ning and ZHOU Wen-ming |
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| Institution: | 1.College of Science,Northwest A & F University,Yangling 712100,Shaanxi Province,China |
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| Abstract: | Thirteen title compounds were synthesized from acetoacetic ester,of which 10 derivatives were first studied.The structures of the compounds were characterized by IR,ESI-MS,1H NMR.The preliminary bioassays results showed that all compounds have differernt inhibition rates on plant pathogenic fungus mycelial growth at concentration of 200 mg/L and mk-1 gives special effect on Fusarium graminearum with 81.4% inhibitation rate at 200 mg/L. |
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| Keywords: | thiazole rings methoxyiminoacetate organic synthesis fungicidal activity |
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