Association Analysis Between Polymorphism of IGF1 Gene and Growth Traits in Rabbit |
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| Authors: | XIAO Chao-neng WENG Ji-mei LI Wei JIANG Zhao-hua LIN Jia-dong LIU Ruo-yu LIN Hong-lin ZU Pan-yu ZHANG Fu-ping |
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| Institution: | 1. Guizhou Key Laboratory of Animal Genetics, Breeding and Reproduction, Key Laboratory of Animal Genetics, Breeding and Reproduction in the Plateau Mountainous Region, Ministry of Education, College of Animal Sciences, Guizhou University, Guiyang 550025, China;
2. Chishui Agriculture and Animal Husbandry Technology Bureau, Chishui 564700, China |
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| Abstract: | This study was aimed to analyze the association of insulin-like growth factor 1 (IGF1) gene polymorphisms with growth traits in rabbit. The technology of DNA pooling, PCR-SSCP and direct sequencing were used to detect the SNP of IGF1 gene. The results showed that T365C was detected in IGF1 gene exon 3 of rabbit. The SNP (C/T) was devised into three genotypes:TT, TC and CC. The relationships between genotypes and growth traits revealed that the birth weight and the weight at 28 days of age in New Zealand rabbit of TT genotype of T365C locus were significantly higher than TC and CC genotypes (P<0.05), the birth weight, the weight at 90 days of age and average daily gain form birth to 90 days of age in Belgian rabbit of TT genotype of T365C locus were significantly higher than TC and CC genotypes (P<0.05), there were no significant difference of the growth traits in other rabbit breeds (P>0.05).The consequence indicated that IGF1 gene was primarily deduced to be a potential major gene or linked to major gene effecting the growth traits of rabbit, and this SNP (T365C) might be a candidate molecular genetic markers to improve the growth traits of rabbit. |
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| Keywords: | rabbit IGF1 gene growth traits |
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