| 饱和水溶液法制备莫能菌素-β-环糊精包合物的研究 |
| |
| 引用本文： | 杨小云,付丽娜,陈洪轩,李见梅,张翠利,信建豪.饱和水溶液法制备莫能菌素-β-环糊精包合物的研究[J].中国畜牧兽医,2017,44(1):289-295. |
| |
| 作者姓名： | 杨小云 付丽娜 陈洪轩 李见梅 张翠利 信建豪 |
| |
| 作者单位： | 黄河科技学院, 郑州 475001 |
| |
| 基金项目： | 黄河科技学院校级项目（KYZR201312） |
| |
| 摘 要： | 为研究莫能菌素包合物的制备工艺，以β-环糊精为包合材料，采用饱和水溶液法制备莫能菌素β-环糊精包合物。用红外光谱法（IR）对包合物进行物相鉴定。以包合率为指标，运用正交设计法，确定最佳处方和工艺条件。IR结果表明，药物与环糊精形成了包合物。当投料比为3：1，包合温度为40℃，搅拌时间1.5 h时，该制备工艺最佳，包合率为57.54%。该制备工艺可行，扩大了莫能菌素的应用，为莫能菌素的剂型改进奠定了基础。
|
| 关 键 词： | 莫能菌素包合物 &beta -环糊精 饱和水溶液法 红外光谱法 包合率 |
| 收稿时间： | 2016-06-17 |
Development of Preparation of Inclusion Compound Carrying Monensin Entrapped by Beta-Cyclodextrin Adopted by Saturated Water Solution |
| |
| YANG Xiao-yun,FU Li-na,CHEN Hong-xuan,LI Jian-mei,ZHANG Cui-li,XIN Jian-hong.Development of Preparation of Inclusion Compound Carrying Monensin Entrapped by Beta-Cyclodextrin Adopted by Saturated Water Solution[J].China Animal Husbandry & Veterinary Medicine,2017,44(1):289-295. |
| |
| Authors: | YANG Xiao-yun FU Li-na CHEN Hong-xuan LI Jian-mei ZHANG Cui-li XIN Jian-hong |
| |
| Institution: | Huanghe Science & Technology College, Zhengzhou 475001, China |
| |
| Abstract: | To study the preparation technology of inclusion compound carrying monensin, monensin was encapsulated with β-cyclodextrin using saturated water solution. The phase identification of inclusion compound was examed by infra-red spectrum (IR).Based on a comprehensive evaluation of inclusion efficiency, the optimal formulation and process conditions of inclusion compound carrying monensin were determined by orthogonal design methods.IR result showed that inclusion compound carrying monensin was formed;The best optimum of the preparation technology were as follows:The proportion of the quality of β-cyclodextrin and monensin was 3:1,the temperature of inclusion was 40℃,and the time of inclusion was 1.5 h. The inclusion rate was 57.54%.This preparation technology was feasible,and enlarged the use of monensin. The study laid a foundation for improvement about dosage form of monensin. |
| |
| Keywords: | inclusion compound of monensin β-cyclodextrin saturated water solution method IR inclusion rate |
|
| 点击此处可从《中国畜牧兽医》浏览原始摘要信息 |
| 点击此处可从《中国畜牧兽医》下载免费的PDF全文 |
|
