Research Advances in Escherichia coli K1 Penetration Across Blood-brain Barrier |
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| Authors: | LING Chen ZHANG Qi-wen SONG Kang JIANG Jian-jun YAN Gen-qiang |
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| Institution: | 1. College of Animal Science and Technology, Shihezi University, Shihezi 832000, China;
2. The General Station of Animal Husbandry and Veterinary Medicine of Division No. 13 of Xinjiang Production and Construction Corps, Hami 839000, China |
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| Abstract: | E.coli K1 strain is a representative strain of neonatal sepsis and meningitis, which causes disease by blood circulation to the brain. The molecular mechanism of E.coli K1 that adhering and invading the brain microvascular endothelial cells (BMECs) and cross the blood brain barrier (BBB) has been focused on by many scholars. In this review, we focused on the gene regulation mechanisms and signaling pathway of E.coli K1 crossing the blood brain barrier to understand the molecular mechanism of the infection caused by E.coli and provide reference for prevention and treatment programs. |
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| Keywords: | Escherichia coli meningitis invasion human brain microvascular endothelial cells (HBMECs) blood-brain barrier |
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