| 鸡传染性法氏囊病免疫复合物疫苗对1日龄中等母源抗体水平雏鸡免疫效果的研究 |
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| 引用本文： | 章振华,李林,景小冬,张建伟,沈佳,史爱华,郑小兰,黄凤军,姜北宇.鸡传染性法氏囊病免疫复合物疫苗对1日龄中等母源抗体水平雏鸡免疫效果的研究[J].中国畜牧兽医,2015,42(12):3338-3343. |
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| 作者姓名： | 章振华 李林 景小冬 张建伟 沈佳 史爱华 郑小兰 黄凤军 姜北宇 |
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| 作者单位： | 北京市农林科学院畜牧兽医研究所, 畜禽疫病防控技术北京市重点实验室, 北京 100097 |
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| 基金项目： | 国家自然科学基金(31402230);北京市自然科学基金(6132014);北京市农林科学院创新能力建设项目(KJCX20140413) |
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| 摘 要： | 将鸡传染性法氏囊病免疫复合物疫苗和BX株活疫苗分别免疫1日龄中等母源抗体水平京红雏鸡,同时免疫1日龄SPF雏鸡作对照,免疫后第9天观察法氏囊病变,免疫后第28天采血测定IBDV中和抗体,并用强毒攻击,计算各组疫苗保护率。结果显示,免疫后第9天,免疫复合物疫苗组SPF雏鸡和京红雏鸡法氏囊均正常,BX株活疫苗组SPF雏鸡法氏囊出现了萎缩病变;免疫后第28天,对照SPF雏鸡和京红雏鸡的免疫复合物疫苗组、BX活疫苗组IBDV中和抗体效价分别为9.2log2、8.5log2和 7.2log2、4.4log2,攻毒保护率均为100%。试验结果表明免疫复合物疫苗免疫1日龄中等水平母源抗体雏鸡效果很好,能产生较高的中和抗体,攻毒保护率能达到100%。
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| 关 键 词： | 鸡传染性法氏囊病 免疫复合物疫苗 法氏囊 保护率 |
| 收稿时间： | 2015-05-28 |
Study on the Immunity Effect of Infectious Bursal Disease Immune Complex Vaccine on One-day Old Moderate Maternal Antibody Chick |
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| ZHANG Zhen-hua,LI Lin,JING Xiao-dong,ZHANG Jian-wei,SHEN Jia,SHI Ai-hua,ZHENG Xiao-lan,HUANG Feng-jun,JIANG Bei-yu.Study on the Immunity Effect of Infectious Bursal Disease Immune Complex Vaccine on One-day Old Moderate Maternal Antibody Chick[J].China Animal Husbandry & Veterinary Medicine,2015,42(12):3338-3343. |
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| Authors: | ZHANG Zhen-hua LI Lin JING Xiao-dong ZHANG Jian-wei SHEN Jia SHI Ai-hua ZHENG Xiao-lan HUANG Feng-jun JIANG Bei-yu |
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| Institution: | Beijing Key Laboratory for Prevention and Control of Infectious Diseases in Livestock and Poultry, Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China |
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| Abstract: | One-day-old moderate maternal antibody Jinghong chickens and SPF chickens were vaccinated with infectious bursal disease (IBD) immune complex (IC) vaccine and BX strain live vaccine,respectively,pathological changes of bursa of fabricius in chickens were observed at the 9th day after immunization.On the 28th day after immunization,blood samples were taken and the IBDV neutralizing antibody were tested,meanwhile experimental chickens were challenged with high virulent IBDV,the protective rates of experimental groups were calculated.The results showed that at the 9th day after immunization,the bursa of fabricius in SPF and Jinghong chickens were normal in IC vaccine group,however atrophic changes of bursa of fabricius in BX strain live vaccine group were shown.At the 28th day after immunization,the IBDV neutralizing antibody of IC vaccine group and BX strain live vaccine group in SPF and Jinghong chickens were 9.2log2,8.5log2,7.2log2 and 4.4log2,respectively,while 100% protection rates were provided.The results provided that IC vaccine had better immunity effect on one-day-old moderate maternal antibody chicken,high levels of neutralizing antibodies against IBDV were produced and protection rates were 100%. |
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| Keywords: | infectious bursal disease (IBD) immune complex vaccine bursa of fabricius protection rate |
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