Experimental and natural infection of early weaned pigs with Salmonella choleraesuis |
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| Authors: | RC Anderson DJ Nisbet SA Buckley KJ Genovese RB Harvey JR Deloach NK Keith LH Stanker |
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| Institution: | BioScience Division of Milk Specialities Company, Dundee, Illinois 60118, USA;United States Department of Agriculture, Agricultural Research Service, Food Animal Protection Research Lab, College Station, TX 77845, USA;BioScience Division of Milk Specialities Company, Dundee, Illinois 60118, USA;Keith Associates, Springfield, Missouri 65804, USA;United States Department of Agriculture, Agricultural Research Service, Food Animal Protection Research Laboratory, College Station, TX 77845, USA |
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| Abstract: | A model for experimental and natural infection of early weaned pigs with Salmonella choleraesuis, the aetiologic agent of swine paratyphoid, has been developed. An oral dose of 108 colony forming units (cfu) of S choleraesuis caused 100 per cent infection of 10 pigs inoculated, as indicated by recovery of the challenge organism from ileocolic lymph nodes collected at necropsy seven days post challenge. Seven of the pigs were observed shedding S choleraesuis at least once post S choleraesuis challenge. The cumulative incidence of shedding was 30 per cent and was sufficient to infect four of 10 pigs exposed naturally. Oral challenges with less than 108 cfu S choleraesuis were less effective in infecting early weaned pigs and did not result in natural transmission. |
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