Topsensterols A–C,Cytotoxic Polyhydroxylated Sterol Derivatives from a Marine Sponge Topsentia sp. |
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| Authors: | Min Chen Xu-Dong Wu Qing Zhao Chang-Yun Wang |
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| Institution: | 1Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China; (M.C.); (X.-D.W.); (Q.Z.);2Marine Science & Technology Institute, College of Environmental Science & Engineering, Yangzhou University, 196#, Huayang West Street, Yangzhou 225127, China |
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| Abstract: | Three new polyhydroxylated sterol derivatives topsensterols A–C (1–3) have been isolated from a marine sponge Topsentia sp. collected from the South China Sea. Their structures were elucidated by detailed analysis of the spectroscopic data, especially the NOESY spectra. Topsensterols A–C (l–3) possess novel 2β,3α,4β,6α-tetrahydroxy-14α-methyl Δ9(11) steroidal nuclei with unusual side chains. Compound 2 exhibited cytotoxicity against human gastric carcinoma cell line SGC-7901 with an IC50 value of 8.0 μM. Compound 3 displayed cytotoxicity against human erythroleukemia cell line K562 with an IC50 value of 6.0 μM. |
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| Keywords: | marine sponge Topsentia sp polyhydroxylated sterol topsensterol cytotoxicity |
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