Protective effects of extract of Ginkgo biloba on diaphragm of diabetic rats |
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| Authors: | LI Xu-sheng CHEN Guo-rong MAO Sun-zhong LEI Kang-fu WANG Fang LI An-le |
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| Institution: | 1. Department of Pathology, Wenzhou Medical College, Wenzhou 325027, China;
2. Department of Biochemistry, Wenzhou Medical College, Wenzhou 325027, China;
3. Center of Experimental Animal, Wenzhou Medical College, Wenzhou 325027, China |
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| Abstract: | AIM: To investigate the effects of extract of Ginkgo biloba (EGb) on diaphragm from diabetic rats. METHODS: Sprague-Dauley rats were divided into three groups: normal control, diabetic group and EGb treatment group. The morphologic changes of diaphragm tissues were studied by light and electron microscopy, the activities of succinate dehydrogenase (SDH), superoxide dismutase (SOD), nitric oxide synthase (NOS) and contents of malondialdehyde (MDA), nitric oxide (NO2-/NO3-) in the diaphragm mitochondria were assayed by spectophotometer, respectively. RESULTS: The activities of SOD, SDH decreased in diabetic diaphragm mitochondria, but the activitiy of NOS, the contents of NO2-/NO3-, MDA increased compared with control group. The activities of SOD, SDH were increased as well as NOS were decreased and the contents of NO2-/NO3-, MDA decreased in EGb treatment group compared with the diabetic group. CONCLUSION: EGb may protects the diaphragm mitochondria of diabetic rats by enhancing the function of respiratory chain, anti-oxidation and decreasing NO level. |
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| Keywords: | Diabetes mellitus experimental Ginkgo biloba Diaphragm Mitochondria |
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