Cell proliferation and nestin expression in cortex and SEZ of MCAO rats |
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| Authors: | CHEN Hu CAI Ding-fang LIANG Hui CHENG Jie-shi |
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| Institution: | 1. Zhongshan Hospital of Fudan University, Fudan University, Shanghai 200032, China;
2. National Key Laboratory of Medical Neurobiology, Shanghai Medical College, Fudan University, Shanghai 200032, China |
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| Abstract: | AIM:To explore the effect of brain ischemia injury on cell proliferation and nestin expression in cortex and subependymal zone (SEZ).METHODS:Using a local brain ischemia model(MCAO), BrdU positive cells of cortex and subependymal zone (SEZ), also nestin positive cells, were observed by immunohistochemistry.RESULTS:BrdU and nestin positive cells in SEZ of MCAO rats were obviously increased. In cortex, only nestin positive cells were observed.CONCLUSION:Neural stem cells in SEZ and cortex were activated after brain ischemia, it may be related with neural recovery after brain ischemia injury. |
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| Keywords: | Brain ischemia Rats Stem cells Cerebral cortex Subependymal zone Nestin |
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