Effects of Shenmai injection on acute myocardial ischemia/reperfusion injury in rats |
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| Authors: | LI Li HUANG Qi-fu |
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| Institution: | 1. Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijin;
1. 100083, China;
2. Department of Pathology, Beijing University of Traditional Chinese Medicine, Beijin;
1. 100029, China |
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| Abstract: | AIM: To observe the effect of Shenmai injection on the acute myocardial ischemia/ reperfusion injury in rats. METHODS: The left-anterior coronary artery was ligated for 10 minutes and then loosed for 15 minutes to establish the animal model of acute myocardial ischemia/reperfusion injury. During the process, electrocardiogram was traced continuously to observe the arrhythmia caused by reperfusion. The levels of SOD, MDA, Na+, K+-ATPase and Ca2+ -ATPase in ventricular myocardium were measured. The mitochondria was observed through electron microscope. RESULTS: Shenmai injection decreased the incidence of arrhythmia caused by reperfusion and shortened its duration. Shenmai injection improved the activity of SOD, Na+, K+-ATPase and Ca2+ -ATPase, decreased the content of MDA in myocardium and relieved the injury of mitochondria. CONCLUSION: Shenmai injection had a protective effect on acute myocardial ischemia/reperfusion injury in rats. The mechanism may be related to relieving the injury caused by oxygen free radical and calcium overload. |
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| Keywords: | Shenmai injection Myocardial reperfusion injury Reactive oxygen species Calcium overload Rats |
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