Effect of tea-polyphenols on the lipoprotein lipase and hepatic lipase activity in atherosclerosis rabbits |
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| Authors: | ZHANG Xiao-gang CHEN Yun-zhen LEI Han WANG Zhou-bi |
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| Institution: | Department of Cardiology, The First Hospital of Chongqing Medical University, Chongqing 400016, China |
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| Abstract: | AIM: To investigate the effect of tea-polyphenols (TP) on the lipoprotein lipase (LPL) and hepatic lipase (HL) activity in atherosclerosis (AS) rabbits. METHODS: The rabbits feeding lipodiet were taken in 200 μg·g-1·d-1 TP through the experiment. The LPL and HL activity in the plasma of rabbits were detected. The LPL activity in the arteria tissue and HL activity in liver tissue were estimated with histochemistry technique. RESULTS: The LPL and HL activity in the plasma were not significantly different between premier and post experiment in AS rabbits (P＞0.05), between AS group and control group (P＞0.05). The LPL activity in the arteria tissue were not different between AS group and control group (P＞0.05). HL activity in liver tissue in AS group was significantly lower than control group (P＜0.05), but TP group was higher than AS group (P＜0.05). In TP group, the TC and LDL-c level in plasma were lower (P＜0.05), and the area of atherosclerosis plaque were smaller than those in AS group (P＜0.05). CONCLUSION: TP increased HL activity in liver tissue in AS rabbits, which correlated with decreasing the TC and LDL-c level in plasma and the area of atherosclerosis plaque. |
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| Keywords: | Tea polyphenols Lipoprotein lipase Hepatic lipase Arteriosclerosis |
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