Influence of Sini decoction on the proliferation and apoptosis of artery smooth muscle cells after balloon injury |
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| Authors: | XUE Ying-sheng WANG Jing-feng NIE Ru-qiong WU Wei-kang LUO Han-chuan CHEN Xiao-wei |
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| Institution: | 1. Cardiovascular Department, the Second Affiliated Hospital, Sun Yat-sen University, Guangzhou 510120, China;
2. Department of Pathophysiology, Sun Yat-sen University, Guangzhou 510089, China |
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| Abstract: | AIM: To investigate the influence of Sini decoction (SND) on the proliferation and apoptosis of rabbit abdominal aorta smooth muscle cells after ballon injury and discuss the effect of vascular smooth muscle cell's (VSMCs) proliferation and apoptosis in post-percutaneous coronary intervention (PCI) restenosis (RS) and the feasibility of SND preventing post-PCI RS. METHODS: The animal model of rabbit abdominal aorta ballon injury was set up and the therapertic group was treated with SND. The shape of proliferative and apoptotic cell were investigated by electron microscope. Immunohistochemistry staining was performed using α-actin,PCNA and Cyclin E monoclonal antibodies. In situ Cell Death Detection Kit was used to identify apoptotic cells. Abdomial aorta angiography was operated in the 84th day subgroup and the stenosis degree was evalued by quantitative angiographic analysis. RESULTS: As compared with the control group, the therapeutic group displayed a lower proliferative percentage and a higher apoptosic percentage (P<0.05). Moreover, the apoptosic peek time was on the 14th day after operation,which was longer than the control group. CONCLUSION: SND effectly inhibited the proliferation of VSMCs and iuduced apoptosis in VSMCs. |
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| Keywords: | Sini decoction Angioplasty balloon Muscle smooth vascular Apoptosis Rabbits |
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