Protective effect of onychin on the human umbilical vein endothelial cells injured by menadione |
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| Authors: | GUO Yu ZHU Bing-yang YAN Feng-xiang HUANG Hong-lin LIAO Duan-fang |
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| Institution: | The Institute of Pharmacy and Pharmacology,Nanhua University,Hengyang 421001,China |
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| Abstract: | AIM: To investigate the protective effect of onychin on the endothelial cells injured by oxidative stress. METHODS: The injured model was established by endothelial cells treated with menadione. The growth inhibitory rate of endothelial cell was determined by MTT assay; NO2-／NO3- concentration in the medium was determined by nitrate reductase assay; eNOS and caveolin-1 protein levels were determined by Western blot. RESULTS: Onychin significantly decreased the growth inhibitory rate of endothelial cells injured by menadione, increased NO2-／NO3- concentration in the medium and eNOS activity and up-regulated caveolin-1 expression. CONCLUSION: Onychin possesses a protective effect against endothelial cell injury induced by menadione via caveolin-1/eNOS pathway. |
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| Keywords: | Onychin Endothelial cell Vitamin K Nitric-oxide synthase |
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